越南接受治疗患者中的HIV抑制情况：胡志明市一家城市公共诊所的HIV病毒载量检测综述
HIV Suppression among Patients on Treatment in Vietnam: A Review of HIV Viral Load Testing in a Public Urban Clinic in Ho Chi Minh City.
作者信息
Trinh T Tony, Montague Brian T, Flanigan Timothy P, Gerard Hoang My
机构信息
Department of General Internal Medicine, Alpert School of Medicine of Brown University, 593 Eddy St., Providence, RI 02909, USA.
出版信息
AIDS Res Treat. 2011;2011:230953. doi: 10.1155/2011/230953. Epub 2011 Feb 7.
Background. There are few reports of HIV viral load (VL) testing among patients on ART in Vietnam. Methods. From a public clinic in Ho Chi Minh City (HCMC), we reviewed cases of VL measurements from adults on ART. Results. We identified 228 cases. Median age was 30 years (27-34), 85% were male, and 77% had a history of IDU. The mean ART duration was 26 months (95% CI 25-27); d4T/3TC/NVP was the most common regimen. Viral suppression was seen in 160/228 (70%). Viremia (>1000 copies/mL) was associated with prior ART exposure (OR 5.68, P < .0001) and immunologic failure (OR 4.69, P = .0001). Targeted testing accounted for 13% of cases, only half of which yielded viremia. Conclusion. We demonstrate a high HIV suppression rate among patients on ART in HCMC, Vietnam. In this setting, routine testing detects viremia missed by targeted testing.
背景。越南接受抗逆转录病毒治疗（ART）的患者中进行HIV病毒载量（VL）检测的报告较少。方法。从胡志明市（HCMC）的一家公共诊所，我们回顾了接受ART的成年人的VL测量病例。结果。我们确定了228例病例。中位年龄为30岁（27 - 34岁），85%为男性，77%有注射吸毒史。ART的平均持续时间为26个月（95%可信区间25 - 27）；司他夫定/拉米夫定/奈韦拉平是最常用的治疗方案。160/228（70%）的患者实现了病毒抑制。病毒血症（>1000拷贝/mL）与既往接受ART治疗（比值比5.68，P <.0001）和免疫失败（比值比4.69，P =.0001）相关。针对性检测占病例的13%，其中只有一半检测出病毒血症。结论。我们证明了越南胡志明市接受ART治疗的患者中HIV抑制率较高。在这种情况下，常规检测能发现针对性检测遗漏的病毒血症。
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