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蛋白聚糖在导致胎盘血栓形成和胎儿生长受限中的作用。

The role of proteoglycans in contributing to placental thrombosis and fetal growth restriction.

作者信息

Said Joanne M

机构信息

Level 7 Research Precinct, The Royal Women's Hospital, Locked Bag 300, Parkville, VIC 3052, Australia; Department of Obstetrics and Gynaecology, University of Melbourne, Parkville 3052, Australia.

出版信息

J Pregnancy. 2011;2011:928381. doi: 10.1155/2011/928381. Epub 2011 Mar 3.

DOI:10.1155/2011/928381
PMID:21490795
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3065915/
Abstract

Fetal growth restriction is an important pregnancy complication that has major consequences for the fetus and neonate as well as an increased risk of long-term morbidity extending into adulthood. The precise aetiology of most cases of fetal growth restriction is unknown although placental thrombosis is a common feature in many of these cases. This paper will outline the potential role of proteoglycans in contributing to placental thrombosis and fetal growth restriction.

摘要

胎儿生长受限是一种重要的妊娠并发症,对胎儿和新生儿有重大影响,并且成年后患长期疾病的风险也会增加。尽管胎盘血栓形成是许多胎儿生长受限病例的常见特征,但大多数病例的确切病因尚不清楚。本文将概述蛋白聚糖在导致胎盘血栓形成和胎儿生长受限方面的潜在作用。

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本文引用的文献

1
Placental biglycan expression is decreased in human idiopathic fetal growth restriction.胎盘 biglycan 表达在人类特发性胎儿生长受限中降低。
Placenta. 2010 Aug;31(8):712-7. doi: 10.1016/j.placenta.2010.05.009. Epub 2010 Jun 29.
2
Decorin expression is decreased in human idiopathic fetal growth restriction.在人类特发性胎儿生长受限中,核心蛋白聚糖的表达降低。
Reprod Fertil Dev. 2010;22(6):949-55. doi: 10.1071/RD09240.
3
Inherited thrombophilia polymorphisms and pregnancy outcomes in nulliparous women.遗传性血栓形成倾向多态性与初产妇妊娠结局的关系。
Obstet Gynecol. 2010 Jan;115(1):5-13. doi: 10.1097/AOG.0b013e3181c68907.
4
Decorin-mediated inhibition of proliferation and migration of the human trophoblast via different tyrosine kinase receptors.饰胶蛋白聚糖通过不同的酪氨酸激酶受体介导对人滋养层细胞增殖和迁移的抑制作用。
Endocrinology. 2008 Dec;149(12):6187-97. doi: 10.1210/en.2008-0780. Epub 2008 Aug 14.
5
Hyperglycemia and adverse pregnancy outcomes.高血糖与不良妊娠结局
N Engl J Med. 2008 May 8;358(19):1991-2002. doi: 10.1056/NEJMoa0707943.
6
Is human placenta proteoglycan remodeling involved in pre-eclampsia?人胎盘蛋白聚糖重塑与子痫前期有关吗?
Glycoconj J. 2008 Jul;25(5):441-50. doi: 10.1007/s10719-007-9090-8. Epub 2007 Dec 27.
7
Fetal growth restriction: the etiology.胎儿生长受限:病因
Clin Obstet Gynecol. 2006 Jun;49(2):228-35. doi: 10.1097/00003081-200606000-00006.
8
Fetal growth restriction: pathogenic mechanisms.胎儿生长受限:致病机制
Clin Obstet Gynecol. 2006 Jun;49(2):219-27. doi: 10.1097/00003081-200606000-00005.
9
High glucose alters proteoglycan expression and the glycosaminoglycan composition in placentas of women with gestational diabetes mellitus and in cultured trophoblasts.高糖改变妊娠糖尿病女性胎盘以及培养的滋养层细胞中的蛋白聚糖表达和糖胺聚糖组成。
Placenta. 2007 Feb-Mar;28(2-3):97-106. doi: 10.1016/j.placenta.2006.02.009. Epub 2006 Apr 21.
10
Thrombophilia in pregnancy: a systematic review.妊娠期血栓形成倾向:一项系统评价。
Br J Haematol. 2006 Jan;132(2):171-96. doi: 10.1111/j.1365-2141.2005.05847.x.