Hattori Y, Higurashi T, Takahashi H, Inamori M, Abe Y, Rino Y, Nakajima A
Gastroenterology Division, Yokohama City University Graduate School of Medicine, Yokohama, Japan.
Case Rep Gastroenterol. 2008 Aug 19;2(2):279-82. doi: 10.1159/000151288.
Valproic acid (VPA) is a commonly prescribed and approved treatment for epilepsy, including Angelman syndrome, throughout the world. However, the long-term administration of drugs like VPA is associated with the possible development of gastric varices and splenic obstruction as a result of chronic pancreatitis. Such cases can be difficult to treat using endoscopy or interventional radiology because of hemodynamic abnormalities; therefore, surgical treatment is often necessary.
丙戊酸（VPA）是一种在全球范围内被广泛处方和批准用于治疗癫痫（包括天使综合征）的药物。然而，长期服用像VPA这样的药物可能会因慢性胰腺炎导致胃静脉曲张和脾梗阻。由于血流动力学异常，此类病例使用内镜检查或介入放射学治疗可能会很困难；因此，通常需要进行手术治疗。
