[暴露于乙酰胆碱的神经细胞膜中钠钾ATP酶活性与蛋白质合成的相关性]
[Correlation of Na,K-ATPase activity and protein synthesis in nerve cell membranes exposed to acetylcholine].
作者信息
Elaev N R
出版信息
Tsitologiia. 1978 Aug;20(8):970-2.
PMID:214915
Abstract
Acetylcholine (10(-6)--10(-3) M) added to the rat brain homogenate increased that activity of microsomal Na, K-ATPase and (14C)-amino acid incorporation in microsomal proteins. Actinomicin D (5.10(-5) M) eliminated the effect of acetylcholine. It is concluded that acetylcholine induced the synthesis of either Na, K-ATPase itself or some other proteins involved in the enzyme activity regulation.
摘要
向大鼠脑匀浆中添加乙酰胆碱（10⁻⁶ - 10⁻³ M）可增加微粒体钠钾ATP酶的活性以及（¹⁴C）氨基酸掺入微粒体蛋白质中的量。放线菌素D（5×10⁻⁵ M）消除了乙酰胆碱的作用。得出的结论是，乙酰胆碱诱导了钠钾ATP酶本身或参与该酶活性调节的其他一些蛋白质的合成。
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