Institute for Molecular Bioscience, The University of Queensland, St. Lucia, Australia.
Dev Dyn. 2011 Jun;240(6):1600-12. doi: 10.1002/dvdy.22640. Epub 2011 Apr 12.
The metanephros is the functional organ in adult amniotes while the mesonephros degenerates. However, parallel tubulogenetic events are thought to exist between mesonephros and metanephros. Mesonephric tubules are retained in males and differentiate into efferent ducts of the male reproductive tract. By examining the murine mesonephric expression of markers of distinct stages and regions of metanephric nephrons during tubule formation and patterning, we provide further evidence to support this common morphogenetic mechanism. Renal vesicle, early proximal and distal tubule, loop of Henle, and renal corpuscle genes were expressed by mesonephric tubules. Vip, Slc6a20b, and Slc18a1 were male-specific. In contrast, mining of the GUDMAP database identified candidate late mesonephros-specific genes, 10 of which were restricted to the male. Among the male-specific genes are candidates for regulating ion/fluid balance within the efferent ducts, thereby regulating sperm maturation and genes marking tubule-associated neurons potentially critical for normal male reproductive tract function.
后肾体是成年羊膜动物的功能器官，中肾退化。然而，中肾和后肾之间被认为存在平行的肾小管发生事件。中肾管在雄性中保留并分化为雄性生殖道的输出导管。通过检查小鼠中肾在肾小管形成和模式形成过程中不同阶段和区域的后肾肾单位标记物的表达，我们提供了进一步的证据支持这种共同的形态发生机制。肾小囊、早期近端和远端小管、亨利氏袢和肾小体基因由中肾管表达。Vip、Slc6a20b 和 Slc18a1 是雄性特异性的。相比之下，对 GUDMAP 数据库的挖掘确定了候选的晚期中肾特异性基因，其中 10 个基因仅局限于雄性。在雄性特异性基因中，有候选基因可以调节输出导管内的离子/流体平衡，从而调节精子成熟，以及标记与小管相关的神经元的基因，这些基因可能对正常的雄性生殖道功能至关重要。
