Centre for Mental Health Research, Australian National University, Canberra, Australia.
Am J Geriatr Psychiatry. 2010 Aug;18(8):723-33. doi: 10.1097/jgp.0b013e3181cdecf1.
To identify neuropsychological predictors of transition from healthy cognitive aging to mild cognitive impairment (MCI) or any mild cognitive disorder (any-MCD) in a community-based longitudinal study of aging.
Longitudinal
Two thousand eighty-two individuals, aged 60–64 years and participating in a prospective epidemiologic study of mental health, and aging were assessed at two time points 4 years apart for MCI using the International Consensus Criteria, the clinical dementia rating scale (CDR, 0.5), or any of a suite of criteria sets for MCDs (any-MCD).
Logistic regression was used to assess the neuropsychological predictors of conversion to diagnosis including the Mini-Mental State Examination, immediate and delayed recall (IR and DR), Digit Backward, Spot-the-Word (STW), Symbol Digits Modalities Test (SDMT), simple and choice reaction time, and reaction time variability.
Of the 2,082 participants with no cognitive impairment in the first wave of data collection, 18 participants were diagnosed with MCI, 32 with CDR 0.5, and 64 participants presented with any-MCD 4 years later. The main neuropsychological predictors of conversion identified in multivariate analyses were measures of IR/DR, STW, Symbol Digit Modalities Task, and reaction time variability.
Although most measures were significant predictors of conversion to MCI or any-MCD when assessed independently, four tests (IR/DR, STW, SDMT, and simple reaction time variability) accounted for the explained variance in diagnosis when all tests were assessed together. When predictive value, stability across clinical categories, and psychometric characteristics were considered together, the reaction time variability measure was the best predictor of future cognitive disorder.
在一项基于社区的老龄化纵向研究中，确定从健康认知老化向轻度认知障碍（MCI）或任何轻度认知障碍（any-MCD）过渡的神经心理学预测因子。
纵向
2082 名年龄在 60-64 岁之间的个体，参与了一项关于心理健康和衰老的前瞻性流行病学研究。在两次相隔 4 年的时间点上，使用国际共识标准、临床痴呆评定量表（CDR，0.5）或任何一套 MCD 标准集（any-MCD）评估了 MCI。
使用逻辑回归来评估转换为诊断的神经心理学预测因子，包括简易精神状态检查、即时和延迟回忆（IR 和 DR）、数字倒背、词语识别测试（STW）、符号数字模态测试（SDMT）、简单和选择反应时间以及反应时间变异性。
在第一次数据收集时没有认知障碍的 2082 名参与者中，18 名被诊断为 MCI，32 名 CDR 为 0.5，64 名参与者在 4 年后出现任何-MCD。多变量分析确定的转换的主要神经心理学预测因子是 IR/DR、STW、符号数字模态任务和反应时间变异性的测量值。
虽然大多数测量值在独立评估时都是转换为 MCI 或 any-MCD 的显著预测因子，但当评估所有测试时，四项测试（IR/DR、STW、SDMT 和简单反应时间变异性）解释了诊断中的可解释方差。当综合考虑预测值、在临床类别中的稳定性和心理测量特征时，反应时间变异性测量值是未来认知障碍的最佳预测因子。
