从正常认知转变为轻度认知障碍的风险因素：“贯穿生命全程”研究
Risk factors of transition from normal cognition to mild cognitive disorder: the PATH through Life Study.
作者信息
Cherbuin Nicolas, Reglade-Meslin Chantal, Kumar Rajeev, Jacomb Patricia, Easteal Simon, Christensen Helen, Sachdev Perminder, Anstey Kaarin J
机构信息
Centre for Mental Health Research, Australian National University, Canberra, A.C.T., Australia.
出版信息
Dement Geriatr Cogn Disord. 2009;28(1):47-55. doi: 10.1159/000229025. Epub 2009 Jul 23.
AIMS
The aim of this study was to identify physical and mental health and lifestyle predictors of transition from normal cognition to mild cognitive disorder (MCD).
METHODS
A total of 2,082 individuals, aged 60-64 years, were assessed at 2 time-points 4 years apart for mild cognitive impairment (MCI) and other MCDs.
RESULTS
The main predictors of conversion to MCI and to other mild cognitive disorders were past alcohol intake, current anxiety and depression medication, increased systolic blood pressure, and past smoking.
CONCLUSION
Participants with a history of smoking or harmful alcohol consumption, hypertension, or who took medication for anxiety or depression were at increased risk of transitioning to MCI or any MCD. Strategies targeted at managing the above risk factors may have benefits in preventing mild cognitive decline in relatively healthy middle-aged individuals living in the community.
目的
本研究旨在确定从正常认知转变为轻度认知障碍（MCD）的身心健康及生活方式预测因素。
方法
共有2082名年龄在60 - 64岁之间的个体，在相隔4年的两个时间点接受了轻度认知障碍（MCI）和其他MCD的评估。
结果
转变为MCI和其他轻度认知障碍的主要预测因素为既往饮酒量、当前用于治疗焦虑和抑郁的药物、收缩压升高以及既往吸烟史。
结论
有吸烟史或有害饮酒史、高血压或服用抗焦虑或抑郁药物的参与者转变为MCI或任何MCD的风险增加。针对上述风险因素的管理策略可能有助于预防社区中相对健康的中年个体出现轻度认知衰退。
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