Zhu Yi, Gao Yaxin, Guo Chuan, Qi Ming, Xiao Ming, Wu Han, Ma Jinhui, Zhong Qian, Ding Hongyuan, Zhou Qiumin, Ali Nawab, Zhou Li, Zhang Qin, Wu Ting, Wang Wei, Sun Cuiyun, Thabane Lehana, Zhang Ling, Wang Tong
Rehabilitation Medicine Center, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
Rehabilitation Medicine Center, The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Municipal Hospital, Gusu School, Nanjing Medical University, Suzhou, China.
Front Aging Neurosci. 2022 Mar 10;14:771413. doi: 10.3389/fnagi.2022.771413. eCollection 2022.
As an intermediate state between normal aging and dementia, mild cognitive impairment (MCI), especially amnestic MCI (aMCI), is a key stage in the prevention and intervention of Alzheimer's disease (AD). Whether dancing could increase the hippocampal volume of seniors with aMCI remains debatable. The aim of this study was to investigate the influence of aerobic dance on hippocampal volume and cognition after 3 months of aerobic dance in older adults with aMCI. In this randomized controlled trial, 68 elderly people with aMCI were randomized to either the aerobic dance group or the control group using a 1:1 allocation ratio. Ultimately, 62 of 68 participants completed this study, and the MRI data of 54 participants were included. A specially designed aerobic dance routine was performed by the dance group three times per week for 3 months, and all participants received monthly healthcare education after inclusion. MRI with a 3.0T MRI scanner and cognitive assessments were performed before and after intervention. High-resolution three-dimensional (3D) T1-weighted anatomical images were acquired for the analysis of hippocampal volume. A total of 35 participants (mean age: 71.51 ± 6.62 years) were randomized into the aerobic dance group and 33 participants (mean age: 69.82 ± 7.74 years) into the control group. A multiple linear regression model was used to detect the association between intervention and the difference of hippocampal volumes as well as the change of cognitive scores at baseline and after 3 months. The intervention group showed greater right hippocampal volume (β [95% CI]: 0.379 [0.117, 0.488], = 0.002) and total hippocampal volume (β [95% CI]: 0.344 [0.082, 0.446], = 0.005) compared to the control group. No significant association of age or gender was found with unilateral or global hippocampal volume. There was a correlation between episodic memory and intervention, as the intervention group showed a higher Wechsler Memory Scale-Revised Logical Memory (WMS-RLM) score (β [95% CI]: 0.326 [1.005, 6.773], = 0.009). Furthermore, an increase in age may cause a decrease in the Mini-Mental State Examination (MMSE) score (β [95% CI]: -0.366 [-0.151, -0.034], = 0.002). In conclusion, 3 months of aerobic dance could increase the right and total hippocampal volumes and improve episodic memory in elderly persons with aMCI. This study was registered on the Chinese Clinical Trial Registry [www.chictr.org.cn], identifier [ChiCTR-INR-15007420].
作为正常衰老与痴呆之间的中间状态，轻度认知障碍（MCI），尤其是遗忘型MCI（aMCI），是阿尔茨海默病（AD）预防和干预的关键阶段。跳舞是否能增加aMCI老年人的海马体积仍存在争议。本研究的目的是调查有氧运动对aMCI老年人进行3个月有氧运动后海马体积和认知的影响。在这项随机对照试验中，68名aMCI老年人以1:1的分配比例随机分为有氧运动组或对照组。最终，68名参与者中有62名完成了本研究，纳入了54名参与者的MRI数据。舞蹈组每周进行3次特别设计的有氧舞蹈套路，持续3个月，所有参与者在纳入后每月接受一次健康教育。在干预前后进行3.0T MRI扫描仪的MRI检查和认知评估。采集高分辨率三维（3D）T1加权解剖图像以分析海马体积。共有35名参与者（平均年龄：71.51±6.62岁）被随机分为有氧运动组，33名参与者（平均年龄：69.82±7.74岁）被分为对照组。使用多元线性回归模型检测干预与海马体积差异以及基线和3个月后认知分数变化之间的关联。与对照组相比，干预组右侧海马体积更大（β[95%CI]：0.379[0.117,0.488]，P = 0.002），总海马体积更大（β[95%CI]：0.344[0.082,0.446]，P = 0.005）。未发现年龄或性别与单侧或整体海马体积有显著关联。情景记忆与干预之间存在相关性，因为干预组的韦氏记忆量表修订版逻辑记忆（WMS-RLM）得分更高（β[95%CI]：0.326[1.005,6.773]，P = 0.009）。此外，年龄增加可能导致简易精神状态检查表（MMSE）得分降低（β[95%CI]：-0.366[-0.151,-0.034]，P = 0.0
