Triantafillidis J K, Merikas E, Malgarinos G, Panteris V, Peros G
Saint Panteleimon General Hospital Nicea, Department of Gastroenterology.
Rev Med Chir Soc Med Nat Iasi. 2009 Jan-Mar;113(1):97-102.
Acute idiopathic pancreatitis seems to represent a rare extraintestinal manifestation of Crohn's disease usually appearing after the establishment of diagnosis of the intestinal disorder. The aim of this study was to describe the clinicoepidemiological characteristics and clinical course of three patients with Crohn's disease who developed acute idiopathic pancreatitis years before the establishment of diagnosis intestinal disease.
All patients were suffering from Crohn's disease. In all patients, an extensive work-up aiming to identify an etiological factor involved in the pathogenesis of acute pancreatitis was negative. The main clinical characteristics of the patients were the young age, the mild or moderate degree of severity of pancreatitis, and the concurrent involvement of small and large bowel from Crohn's disease in two of them. There was no preference for either male or female sex. The course of pancreatitis was favorable in all patients. During the follow-up period, ranging from 2 to 8 years, no exacerbation of pancreatitis was noticed.
This case-series suggests that acute idiopathic pancreatitis could precede diagnosis of Crohn's disease. Clinicians must bear in mind the possibility of the existence of Crohn's disease when they are confronting a young patient with clinical and laboratory features of acute idiopathic pancreatitis.
急性特发性胰腺炎似乎是克罗恩病一种罕见的肠外表现，通常在肠道疾病诊断确立后出现。本研究的目的是描述3例在肠道疾病诊断确立数年前发生急性特发性胰腺炎的克罗恩病患者的临床流行病学特征及临床病程。
所有患者均患有克罗恩病。对所有患者进行了旨在确定参与急性胰腺炎发病机制的病因的全面检查，结果均为阴性。患者的主要临床特征为年龄较轻、胰腺炎严重程度为轻或中度，其中2例患者的小肠和大肠同时受到克罗恩病累及。男女无明显差异。所有患者胰腺炎病程均良好。在2至8年的随访期内，未发现胰腺炎加重。
该病例系列提示急性特发性胰腺炎可能先于克罗恩病的诊断出现。临床医生在面对具有急性特发性胰腺炎临床和实验室特征的年轻患者时，必须牢记存在克罗恩病的可能性。
