School of Chemistry and Biochemistry and the Parker H. Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, Georgia 30332, United States.
Org Lett. 2011 May 20;13(10):2536-9. doi: 10.1021/ol200570u. Epub 2011 Apr 14.
The indanomycin biosynthetic gene (idm) cluster was recently identified from Streptomyces antibioticus NRRL 8167. The disruption of one of these genes, idmH, and the increased production of a previously unreported metabolite in this mutant is reported. The structure of this compound was elucidated and was shown to possess a linear tetraene. This metabolite is not a logical biosynthetic intermediate of indanomycin but instead is likely an alternate product of the pathway.
吲哚霉素生物合成基因（idm）簇最近从链霉菌属 NRRL 8167 中被鉴定出来。报告了其中一个基因 idmH 的缺失以及该突变体中一种以前未报道的代谢产物的产量增加。该化合物的结构被阐明，并显示出具有线性四烯。该代谢物不是吲哚霉素的逻辑生物合成中间体，而是该途径的替代产物。
