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海洋吡咯生物碱。

Marine Pyrrole Alkaloids.

机构信息

Department of Chemistry, Organic Chemistry Section, Johannes Gutenberg University, Duesbergweg 10-14, 55128 Mainz, Germany.

出版信息

Mar Drugs. 2021 Sep 10;19(9):514. doi: 10.3390/md19090514.

DOI:10.3390/md19090514
PMID:34564176
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8471394/
Abstract

Nitrogen heterocycles are essential parts of the chemical machinery of life and often reveal intriguing structures. They are not only widespread in terrestrial habitats but can also frequently be found as natural products in the marine environment. This review highlights the important class of marine pyrrole alkaloids, well-known for their diverse biological activities. A broad overview of the marine pyrrole alkaloids with a focus on their isolation, biological activities, chemical synthesis, and derivatization covering the decade from 2010 to 2020 is provided. With relevant structural subclasses categorized, this review shall provide a clear and timely synopsis of this area.

摘要

氮杂环是生命化学机制的重要组成部分，常常呈现出引人入胜的结构。它们不仅广泛存在于陆地生境中，而且还经常作为海洋环境中的天然产物出现。本综述重点介绍了海洋吡咯生物碱这一重要的化合物类别，它们以多样的生物活性而闻名。本文提供了 2010 年至 2020 年这十年来海洋吡咯生物碱的广泛概述，包括它们的分离、生物活性、化学合成和衍生化，重点介绍了其结构分类。通过对相关结构亚类进行分类，本文将对这一领域进行清晰及时的综述。

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Mar Genomics. 2021 Feb;55:100803. doi: 10.1016/j.margen.2020.100803. Epub 2020 Jul 9.
9
Polyphenolic Fraction Obtained From Marine Plant and Thalassiolin B Exert Cytotoxic Effects in Colorectal Cancer Cells and Arrest Tumor Progression in a Xenograft Mouse Model.从海洋植物中获得的多酚组分和海松素B对结肠癌细胞具有细胞毒性作用，并在异种移植小鼠模型中阻止肿瘤进展。
Front Pharmacol. 2020 Nov 30;11:592985. doi: 10.3389/fphar.2020.592985. eCollection 2020.
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Marine Anticancer Agents: An Overview with a Particular Focus on Their Chemical Classes.海洋抗癌药物：概述及其化学类别特别关注。
Mar Drugs. 2020 Dec 4;18(12):619. doi: 10.3390/md18120619.