a College of Pharmaceutical Sciences, Zhejiang University , Hangzhou , 310058 , P.R. China.
Nat Prod Res. 2013;27(23):2161-7. doi: 10.1080/14786419.2013.793688. Epub 2013 May 2.
Four indanomycin-related antibiotics 2-5 were isolated from the cultured broth of marine Streptomyces antibioticus strain PTZ0016. Their structures were characterised as 16-deethylindanomycin (2), iso-16-deethylindanomycin (3), 16-deethylindanomycin methyl ester (4) and iso-16-deethylindanomycin methyl ester (5) on the basis of NMR, HR-ESI-MS and CD evidences. Compounds 3-5 are new additions to the class of indanomycin antibiotics. All isolated compounds showed in vitro activity against Staphylococcus aureus with minimal inhibitory concentration at 4.0-8.0 μg/ml.
从海洋放线菌菌株 PTZ0016 的发酵液中分离得到了四种与吲达霉素相关的抗生素 2-5。根据 NMR、HR-ESI-MS 和 CD 证据，它们的结构被表征为 16-去乙基吲达霉素（2）、异-16-去乙基吲达霉素（3）、16-去乙基吲达霉素甲酯（4）和异-16-去乙基吲达霉素甲酯（5）。化合物 3-5 是吲达霉素抗生素类的新成员。所有分离得到的化合物对金黄色葡萄球菌均显示出体外活性，最小抑菌浓度为 4.0-8.0 μg/ml。
