三组分[2+2+2]环加成反应：终端炔烃、内部炔烃和烯烃与 NbCl3 反应生成 1,3,4,5-四取代 1,3-环己二烯。
NbCl3-catalyzed three-component [2 + 2 + 2] cycloaddition reaction of terminal alkynes, internal alkynes, and alkenes to 1,3,4,5-tetrasubstituted 1,3-cyclohexadienes.
机构信息
Department of Chemistry and Materials Engineering, Faculty of Chemistry, Materials and Bioengineering, Kansai University, Suita, Osaka, Japan.
出版信息
Org Lett. 2011 May 20;13(10):2568-71. doi: 10.1021/ol200662e. Epub 2011 Apr 14.
PMID:21491900
Abstract
Three-component [2 + 2 + 2] cycloaddition of terminal alkynes, internal alkynes, and terminal alkenes is achieved using an NbCl(3)(DME) catalyst, leading to 1,3,4,5-substituted 1,3-cyclohexadienes in excellent yields with high chemo- and regioselectivity.
摘要
三组分[2 + 2 + 2]环加成反应，使用 NbCl(3)(DME)催化剂，使末端炔烃、内部炔烃和末端烯烃反应，以高产率和高化学选择性和区域选择性得到 1,3,4,5-取代的 1,3-环己二烯。
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