Akama Fumiaki, Nishino Ryo, Makino Seiya, Kobayashi Kiyoshi, Kamikaseda Kazufumi, Nagano Jun, Koga Yasuhiro
Laboratory for Infectious Diseases, Tokai University School of Medicine, Isehara, Japan.
Scand J Gastroenterol. 2011 Jul;46(7-8):831-6. doi: 10.3109/00365521.2011.574730. Epub 2011 Apr 15.
To examine whether a probiotic strain, Lactobacillus gasseri OLL2716 (LG21), can protect the gastric mucosal integrity from aspirin using urinary sucrose excretion (USE) test.
In the study using high-dose aspirin, the USE tests were carried out in 29 volunteers before and after LG21 treatment for 4 weeks. In the study using patients undergoing low-dose aspirin therapy, USE tests were performed in 37 subjects who took LG21 for 16 weeks. Stool occult blood was examined by the guaiac method.
In the former study, the elevation in the USE value after aspirin loading significantly decreased after LG21 treatment (Median ± SD; 0.244 ± 0.237 vs. 0.208 ± 0.112%, p = 0.018). In the latter study, the USE value significantly decreased in the period with LG21 treatment (p = 0.033), while no significant difference was found in the period without LG21 (p = 0.113). The number of positive occult blood tests decreased during LG21 treatment.
The regular ingestion of LG21 may protect the integrity of the gastric mucosal permeability against aspirin.
使用尿蔗糖排泄（USE）试验来检验益生菌菌株加氏乳杆菌OLL2716（LG21）是否能保护胃黏膜完整性免受阿司匹林的损害。
在使用高剂量阿司匹林的研究中，对29名志愿者在LG21治疗4周前后进行了USE试验。在使用接受低剂量阿司匹林治疗患者的研究中，对37名服用LG21 16周的受试者进行了USE试验。采用愈创木脂法检测粪便潜血。
在前一项研究中，LG21治疗后阿司匹林负荷后USE值的升高显著降低（中位数±标准差；0.244±0.237对0.208±0.112%，p = 0.018）。在后一项研究中，LG21治疗期间USE值显著降低（p = 0.033），而在无LG21治疗期间未发现显著差异（p = 0.113）。LG21治疗期间潜血试验阳性次数减少。
定期摄入LG21可能保护胃黏膜通透性的完整性免受阿司匹林的影响。
