植物乳杆菌 OLL2716 对幽门螺杆菌阴性功能性消化不良的改善作用：一项随机对照研究。
The Ameliorating Effect of Lactobacillus gasseri OLL2716 on Functional Dyspepsia in Helicobacter pylori-Uninfected Individuals: A Randomized Controlled Study.
机构信息
Food Science Research Laboratories, Meiji Co. Ltd., Odawara, Japan.
出版信息
Digestion. 2017;96(2):92-102. doi: 10.1159/000479000. Epub 2017 Jul 29.
BACKGROUND/AIMS: Probiotics appear to improve Helicobacter pylori-associated dyspepsia via an inhibitory effect on H. pylori; however, uncertainty exists regarding their effects in H. pylori-uninfected individuals. We evaluated the efficacy of Lactobacillus gasseri OLL2716 (L. gasseri OLL2716) on H. pylori-uninfected individuals with functional dyspepsia (FD).
METHODS
A double-blind, parallel-group, placebo-controlled, randomized, controlled trial was performed. Participants were randomly assigned to ingest L. gasseri OLL2716-containing yogurt (L. gasseri OLL2716 group) or L. gasseri OLL2716-free yogurt (placebo group) for 12 weeks. Participants completed questionnaires that dealt with a global assessment as well as symptom severity. The per-protocol (PP) population was evaluated for efficacy in accordance with a plan prepared beforehand.
RESULTS
Randomization was performed on 116 individuals; the PP population consisted of 106 individuals (mean age 42.8 ± 9.0). The impressions regarding the overall effect on gastric symptoms were more positive in the L. gasseri OLL2716 group compared to that in the placebo group (statistical trend; p = 0.073). The elimination rate for major FD symptoms was 17.3 and 35.3% in the placebo and L. gasseri OLL2716 groups respectively (p = 0.048).
CONCLUSION
L. gasseri OLL2716 has beneficial effects on FD without H. pylori involvement.
背景/目的：益生菌似乎通过抑制幽门螺杆菌对与幽门螺杆菌相关的消化不良有改善作用，但在未感染幽门螺杆菌的个体中其效果尚不确定。我们评估了干酪乳杆菌 OLL2716（L. gasseri OLL2716）对功能性消化不良（FD）且无幽门螺杆菌感染的个体的疗效。
方法
进行了一项双盲、平行组、安慰剂对照、随机对照试验。参与者被随机分配摄入含有干酪乳杆菌 OLL2716 的酸奶（L. gasseri OLL2716 组）或不含干酪乳杆菌 OLL2716 的酸奶（安慰剂组），为期 12 周。参与者完成了涉及整体评估以及症状严重程度的问卷。根据事先制定的计划，对符合方案（PP）人群进行疗效评估。
结果
对 116 人进行了随机分组；PP 人群由 106 人组成（平均年龄 42.8 ± 9.0）。与安慰剂组相比，L. gasseri OLL2716 组对胃症状整体效果的印象更为积极（统计学趋势；p = 0.073）。主要 FD 症状的消除率在安慰剂组和 L. gasseri OLL2716 组分别为 17.3%和 35.3%（p = 0.048）。
结论
L. gasseri OLL2716 对无幽门螺杆菌感染的 FD 有有益作用。
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