神经纤毛蛋白和神经纤毛相关分子作为胰腺腺癌的新分子靶点。

Neuropilin and neuropilin associated molecules as new molecular targets in pancreatic adenocarcinoma.

机构信息

Institute of Pathology, University Hospital Carl Gustav Carus, University of Technology Dresden, Fetscherstrasse 74, Dresden, Germany.

出版信息

Anticancer Agents Med Chem. 2011 Jun;11(5):442-7. doi: 10.2174/187152011795677481.

DOI:10.2174/187152011795677481

PMID:21492075

Abstract

The Neuropilin receptors are increasingly recognized as receptors for vascular endothelial growth factors like VEGF-A and VEGF-C as well as other important growth factors like HGF and FGF in human vasculature and in tumor cells. More and more studies show an important role of Neuropilin in cancer biology suggesting that these transmembrane proteins might be an emerging target for new therapies in different subsets of cancer. Interestingly, blocking the adaptor protein GIPC1/Synectin that interacts with Neuropilin might be another interesting avenue for therapy. This review summarizes unfolding scientific data on these receptors and its interacting protein GIPC1/Synectin as molecular targets for therapy in pancreatic ductal adenocarcinoma.

摘要

神经纤毛蛋白受体越来越被认为是血管内皮生长因子（如 VEGF-A 和 VEGF-C）以及人类血管和肿瘤细胞中其他重要生长因子（如 HGF 和 FGF）的受体。越来越多的研究表明神经纤毛蛋白在癌症生物学中具有重要作用，表明这些跨膜蛋白可能成为不同癌症亚群新疗法的新兴靶点。有趣的是，阻断与神经纤毛蛋白相互作用的衔接蛋白 GIPC1/神经束蛋白可能是另一种有前途的治疗途径。本文综述了这些受体及其相互作用蛋白 GIPC1/神经束蛋白作为胰腺导管腺癌治疗靶点的最新科学数据。