Masters Program in Clinical Sciences, University of Texas Southwestern Medical Center, Dallas, TX, USA.
J Investig Med. 2012 Apr;60(4):643-63. doi: 10.2310/JIM.0b013e31824a4d79.
With the continued failures of both early diagnosis and treatment options for pancreatic cancer, it is now time to comprehensively evaluate the role of the immune system on the development and progression of pancreatic cancer. It is important to develop strategies that harness the molecules and cells of the immune system to treat this disease. This review will focus primarily on the role of immune cells in the development and progression of pancreatic ductal adenocarcinoma and to evaluate what is known about the interaction of immune cells with the tumor microenvironment and their role in tumor growth and metastasis. We will conclude with a brief discussion of therapy for pancreatic cancer and the potential role for immunotherapy. We hypothesize that the role of the immune system in tumor development and progression is tissue specific. Our hope is that better understanding of this process will lead to better treatments for this devastating disease.
由于胰腺癌的早期诊断和治疗选择持续失败，现在是时候全面评估免疫系统在胰腺癌发展和进展中的作用了。重要的是要制定利用免疫系统的分子和细胞来治疗这种疾病的策略。这篇综述将主要关注免疫细胞在胰腺导管腺癌发展和进展中的作用，并评估已知的免疫细胞与肿瘤微环境的相互作用及其在肿瘤生长和转移中的作用。最后，我们将简要讨论胰腺癌的治疗方法和免疫疗法的潜在作用。我们假设免疫系统在肿瘤发生和发展中的作用是组织特异性的。我们希望更好地了解这一过程将为这种毁灭性疾病带来更好的治疗方法。
