Department of Pathology, Medical Faculty, Hacettepe University, Ankara, Turkey.
APMIS. 2011 Apr;119(4-5):309-16. doi: 10.1111/j.1600-0463.2011.02736.x. Epub 2011 Mar 22.
Accumulated evidence has shown the importance of Epstein-Barr virus in the pathogenesis of various lymphomas. This study aimed to determine the prevalence of Epstein-Barr virus expression and its effect on survival amongst diffuse large B-cell lymphoma (DLBCL) cases from two large tertiary care centres in Turkey with a particular interest in identifying cases of 'Epstein-Barr virus-positive DLBCL of the elderly'. Diffuse large B-cell lymphoma cases diagnosed between 1999 and 2009 were retrieved and 340 cases were used to construct tissue microarrays. The presence of Epstein-Barr virus small ribonucleic acids was examined by in situ hybridization using Epstein-Barr virus (EBV)-encoded small RNA (EBER) oligonucleotides. A total of 18 cases (5.3%) showed Epstein-Barr virus expression. Twelve cases were classified as Epstein-Barr virus-positive DLBCL of the elderly. Epstein-Barr virus-positive DLBCL cases showed a significantly inferior overall survival as compared with Epstein-Barr virus-negative cases (p < 0.001). In our study group Epstein-Barr virus expression is not prevalent in DLBCLs. Epstein-Barr virus-positive DLBCL of the elderly is also rare in the Turkish population. The presence of Epstein-Barr virus, however, is associated with poor prognosis.
已有大量证据表明，EB 病毒在多种淋巴瘤的发病机制中具有重要作用。本研究旨在确定 EB 病毒表达的流行率及其对土耳其两家大型三级护理中心弥漫性大 B 细胞淋巴瘤（DLBCL）病例生存的影响，特别关注鉴定“老年 EBV 阳性 DLBCL”病例。检索了 1999 年至 2009 年间诊断的弥漫性大 B 细胞淋巴瘤病例，并使用 340 例病例构建组织微阵列。使用 Epstein-Barr 病毒（EBV）编码的小 RNA（EBER）寡核苷酸通过原位杂交检查 EB 病毒小核糖核酸的存在。共有 18 例（5.3%）显示 EB 病毒表达。12 例被归类为老年 EBV 阳性 DLBCL。与 EBV 阴性病例相比，EBV 阳性 DLBCL 病例的总生存率明显较低（p < 0.001）。在我们的研究组中，DLBCL 中 EB 病毒表达并不普遍。老年 EBV 阳性 DLBCL 在土耳其人群中也很少见。然而，EB 病毒的存在与预后不良相关。
