Department of Family Medicine, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Korea.
Cardiovasc Diabetol. 2011 Apr 15;10:30. doi: 10.1186/1475-2840-10-30.
Increased fasting plasma glucose (FPG), which includes impaired fasting glucose (IFG), impaired glucose tolerance (IGT), and diabetes, is a risk factor for arterial stiffness. While IFG is widely accepted as a cardiovascular risk factor, recent studies have argued that subjects with high-normal glucose level were characterized by a high incidence of cardiovascular disease. The purpose of this study is to investigate the relationship between FPG and arterial stiffness in non-diabetic healthy subjects.
We recruited 697 subjects who visited the health promotion center of a university hospital from May 2007 to August 2008. Age, sex, body mass index (BMI), resting heart rate, smoking habits, alcohol intake, exercise, blood pressure, medical history, FPG, lipid profile, high sensitivity C-reactive protein (hs-CRP), and Brachial-ankle pulse wave velocity (ba-PWV) were measured. We performed correlation and multiple linear regression analyses to divide the research subjects into quartiles: Q1(n=172), 65 mg/dL≤FPG<84 mg/dL; Q2(n=188), 84 mg/dL≤FPG<91 mg/dl; Q3(n=199), 91 mg/dL≤FPG<100 mg/dL; Q4(n=138), 100 mg/dL≤FPG<126 mg/dL.
FPG has an independent, positive association with ba-PWV in non-diabetic subjects after correcting for confounding variables, including age, sex, BMI, blood pressure, resting heart rate, hs-CRP, lipid profile, and behavioral habits. The mean ba-PWV of the high-normal glucose group (Q3, 1384 cm/s) was higher than that of the low-normal glucose group (1303±196 cm/s vs.1328±167 cm/s, P<0.05). The mean ba-PWV value in the IFG group (1469±220 cm/s) was higher than that in the normoglycemic group (P<0.05, respectively).
An increase in FPG, even within the normal range, was associated with aggravated arterial stiffness. Further research is needed to determine the glycemic target value for the prevention of arterial stiffness in clinical and public health settings.
空腹血糖（FPG）升高，包括空腹血糖受损（IFG）、葡萄糖耐量受损（IGT）和糖尿病，是动脉僵硬的一个危险因素。虽然 IFG 被广泛认为是心血管风险因素，但最近的研究认为，高正常血糖水平的受试者具有更高的心血管疾病发病率。本研究旨在探讨非糖尿病健康受试者中 FPG 与动脉僵硬之间的关系。
我们招募了 2007 年 5 月至 2008 年 8 月期间在大学医院健康促进中心就诊的 697 名受试者。测量年龄、性别、体重指数（BMI）、静息心率、吸烟习惯、饮酒量、运动、血压、既往病史、FPG、血脂谱、高敏 C 反应蛋白（hs-CRP）和肱踝脉搏波速度（ba-PWV）。我们进行了相关性和多元线性回归分析，将研究对象分为四组：Q1（n=172），FPG65mg/dL≤<84mg/dL；Q2（n=188），84mg/dL≤<91mg/dL；Q3（n=199），91mg/dL≤<100mg/dL；Q4（n=138），FPG100mg/dL≤<126mg/dL。
在纠正混杂因素（包括年龄、性别、BMI、血压、静息心率、hs-CRP、血脂谱和行为习惯）后，非糖尿病受试者的 FPG 与 ba-PWV 呈独立、正相关。高正常血糖组（Q3，1384cm/s）的平均 ba-PWV 高于低正常血糖组（1303±196cm/s 与 1328±167cm/s，P<0.05）。IFG 组的平均 ba-PWV 值（1469±220cm/s）高于血糖正常组（P<0.05）。
即使在正常范围内，FPG 的升高也与动脉僵硬的加重有关。需要进一步研究确定在临床和公共卫生环境中预防动脉僵硬的血糖目标值。
