拉丁美洲代谢综合征的流行情况及其与亚临床颈动脉粥样硬化的关系：CARMELA 横断面研究。
Prevalence of the metabolic syndrome in Latin America and its association with sub-clinical carotid atherosclerosis: the CARMELA cross sectional study.
机构信息
Medical Research Unit on Clinical Epidemiology, Mexican Social Security Institute, Mexico City, Mexico.
出版信息
Cardiovasc Diabetol. 2009 Sep 26;8:52. doi: 10.1186/1475-2840-8-52.
BACKGROUND
Metabolic syndrome increases cardiovascular risk. Limited information on its prevalence in Latin America is available. The Cardiovascular Risk Factor Multiple Evaluation in Latin America (CARMELA) study included assessment of metabolic syndrome in 7 urban Latin American populations.
METHODS
CARMELA was a cross-sectional, population-based, observational study conducted in Barquisimeto, Venezuela; Bogota, Colombia; Buenos Aires, Argentina; Lima, Peru; Mexico City, Mexico; Quito, Ecuador; and Santiago, Chile. The prevalence of metabolic syndrome, defined according to the National Cholesterol Education Program Adult Treatment Panel III (NCEP ATP III), and associated carotid atherosclerosis were investigated in 11,502 participants aged 25 to 64 years.
RESULTS
Across CARMELA cities, metabolic syndrome was most prevalent in Mexico City (27%) and Barquisimeto (26%), followed by Santiago (21%), Bogota (20%), Lima (18%), Buenos Aires (17%), and Quito (14%). In nondiabetic participants, prevalence was slightly lower but followed a comparable ranking. Overall, 59%, 59%, and 73% of women with high triglycerides, hypertension, or glucose abnormalities, respectively, and 64%, 48% and 71% of men with abdominal obesity, hypertension, or glucose abnormalities, respectively, had the full metabolic syndrome. Prevalence of metabolic syndrome increased with age, markedly so in women. Mean common carotid artery intima-media thickness (CCAIMT) and prevalence of carotid plaque increased steeply with increasing numbers of metabolic syndrome components; mean CCAIMT was higher and plaque more prevalent in participants with metabolic syndrome than without.
CONCLUSION
The prevalence of metabolic syndrome and its components by NCEP ATP III criteria was substantial across cities, ranging from 14% to 27%. CARMELA findings, including evidence of the association of metabolic syndrome and carotid atherosclerosis, should inform appropriate clinical and public health interventions.
背景
代谢综合征会增加心血管疾病风险。目前拉丁美洲地区关于代谢综合征流行情况的信息有限。心血管风险因素在拉丁美洲的多重评估（CARMELA）研究纳入了 7 个拉丁美洲城市的人群，对代谢综合征进行了评估。
方法
CARMELA 是一项在委内瑞拉巴基西梅托、哥伦比亚波哥大、阿根廷布宜诺斯艾利斯、秘鲁利马、墨西哥墨西哥城、厄瓜多尔基多和智利圣地亚哥进行的横断面、基于人群、观察性研究。该研究纳入了 11502 名年龄在 25 至 64 岁之间的参与者，调查了根据国家胆固醇教育计划成人治疗专家组 III（NCEP ATP III）定义的代谢综合征的流行情况，以及相关的颈动脉粥样硬化情况。
结果
在所调查的 CARMELA 城市中，代谢综合征在墨西哥城（27%）和巴基西梅托（26%）最为普遍，其次是圣地亚哥（21%）、波哥大（20%）、利马（18%）、布宜诺斯艾利斯（17%）和基多（14%）。在非糖尿病参与者中，患病率略低，但排名相当。总体而言，分别有 59%、59%和 73%的女性具有高甘油三酯、高血压或葡萄糖异常，以及分别有 64%、48%和 71%的男性具有腹型肥胖、高血压或葡萄糖异常，具备完整的代谢综合征。代谢综合征的患病率随年龄增长而增加，女性尤为明显。随着代谢综合征组分数量的增加，颈总动脉内膜中层厚度（CCAIMT）的平均值和颈动脉斑块的患病率均急剧增加；患有代谢综合征的参与者的 CCAIMT 平均值更高，斑块更常见。
结论
根据 NCEP ATP III 标准，在所调查的城市中，代谢综合征及其组分的患病率差异较大，范围在 14%至 27%之间。CARMELA 的研究结果，包括代谢综合征与颈动脉粥样硬化之间关联的证据，应该为适当的临床和公共卫生干预措施提供信息。
Zotero 插件