Department of Family Medicine, Yonsei University College of Medicine, 23 Yongmun-ro, Yongin-si, Gyeonggi-do 449-930, Republic of Korea.
Arch Gerontol Geriatr. 2012 Jan-Feb;54(1):206-9. doi: 10.1016/j.archger.2011.03.006. Epub 2011 Apr 13.
Leukaraiosis and a higher level of pulse pressure are well-recognized as associated with cardiovascular disease, vascular angiopathy, and geriatric syndrome. A cross-sectional study was conducted to examine the relation between pulse pressure and leukoaraiosis based on brain magnetic resonance imaging (MRI) scans in the apparently healthy elderly (147 men aged 60-84 years and 89 women aged 60-82 years). The odds ratios (OR) and 95% confidence interval (CI) for leukoaraiosis were calculated using multivariate logistic regression analyses according to each quartile of pulse pressure. The percentage of leukoaraiosis gradually increased in accordance with pulse pressure quartiles: 5.1%, 8.6%, 16.1%, and 26.2% for men, and 4.5%, 8.7%, 13.0%, and 23.8% for women. In comparison with subjects in the lowest quartile, the OR (95%CI) for leukoaraiosis in the highest quartile was 6.80 (1.20-38.45) in men after adjusting for age, body mass index, fasting plasma glucose, HDL-cholesterol, triglyceride (TG), smoking status, and current drinking. However, the relationship was not evident in women after adjusting for the same co-variables. In conclusion, pulse pressure was found to be independently associated with leukoaraiosis regardless of classical cardiovascular risk factors in elderly men.
脑白质疏松症与较高的脉压均被认为与心血管疾病、血管病变和老年综合病症有关。本研究通过对磁共振成像（MRI）检查的健康老年人（147 名男性，年龄 60-84 岁；89 名女性，年龄 60-82 岁）进行横断面研究，以探讨脉压与脑白质疏松症之间的关系。根据脉压的四分位数，采用多变量 logistic 回归分析计算脑白质疏松症的比值比（OR）及其 95%置信区间（CI）。男性的脑白质疏松症比例依次随脉压四分位数增加而升高，分别为 5.1%、8.6%、16.1%和 26.2%；女性分别为 4.5%、8.7%、13.0%和 23.8%。与最低四分位数组相比，校正年龄、体重指数、空腹血糖、高密度脂蛋白胆固醇、甘油三酯、吸烟状况和当前饮酒状况后，男性脉压最高四分位数组发生脑白质疏松症的 OR（95%CI）为 6.80（1.20-38.45）。然而，在校正相同协变量后，女性中这种相关性不明显。总之，脉压与脑白质疏松症独立相关，而与老年男性的经典心血管危险因素无关。
