Biostatistics and Epidemiology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, WV 26505, USA.
Cytokine. 2011 Jul;55(1):74-8. doi: 10.1016/j.cyto.2011.03.025. Epub 2011 Apr 13.
Our aim was to examine the relationship between the level of the inflammatory markers, C-reactive protein (CRP) and interleukin-6 (IL-6), and posttraumatic stress disorder (PTSD) symptomology in a random sample of 115 police officers. CRP was measured in citrated plasma using a particle enhanced immunonepholometric assay and IL-6 was measured in serum with a solid-phase quantitative sandwich ELISA. The presence of high PTSD symptomology was defined as having an Impact of Event Scale score (IES) of ≥ 26 compared to<26 (low PTSD symptomology). 28% of the officers had high PTSD symptomology. Mean levels of CRP and IL-6 did not differ significantly between officers with high PTSD symptomology and those with low symptomology (CRP: 0.76 mg/l vs. 0.97 mg/l; IL-6: 2.03 pg/ml vs. 1.74 pg/ml). We found no association of CRP and IL-6 levels with PTSD symptomology. This study was limited by sample size and its cross-sectional study design. A lack of association may occur if either CRP or IL-6 is elevated only at the onset of PTSD symptomology, or if inflammation is related to specific key components that define PTSD. Further research examining these relationships in a larger population may be worthwhile.
我们的目的是在 115 名随机抽取的警察样本中检查炎症标志物 C-反应蛋白（CRP）和白细胞介素-6（IL-6）的水平与创伤后应激障碍（PTSD）症状之间的关系。使用颗粒增强免疫比浊测定法测量柠檬酸血浆中的 CRP，使用固相定量夹心 ELISA 测量血清中的 IL-6。高 PTSD 症状的存在定义为事件影响量表（IES）评分≥26 与<26（低 PTSD 症状）相比。28%的警察有高 PTSD 症状。高 PTSD 症状组和低 PTSD 症状组的 CRP 和 IL-6 平均水平无显著差异（CRP：0.76mg/l 与 0.97mg/l；IL-6：2.03pg/ml 与 1.74pg/ml）。我们发现 CRP 和 IL-6 水平与 PTSD 症状之间没有关联。这项研究受到样本量和横断面研究设计的限制。如果 CRP 或 IL-6 仅在 PTSD 症状发作时升高，或者炎症与定义 PTSD 的特定关键成分有关，则可能不会出现关联。进一步在更大人群中研究这些关系可能是值得的。
