Na Kyoung-Sa, Kim Eun-Kyoung, Park Jong-Tae
Department of Psychiatry, Gachon University Gil Medical Center, Incheon, Republic of Korea.
Department of Occupational and Environmental Medicine, Korea Workers' Compensation & Welfare Service, Ansan, Republic of Korea.
J Affect Disord. 2017 Oct 15;221:254-258. doi: 10.1016/j.jad.2017.06.015. Epub 2017 Jun 13.
Recent studies have reported that adiponectin-mediated neuromolecular pathways are involved in fear extinction, implying that adiponectin may be an important biological marker for posttraumatic stress disorder (PTSD). However, no study has investigated the association between adiponectin and patients with PTSD.
We examined plasma adiponectin levels, high-sensitivity C-reactive protein (hs-CRP), and psychopathological factors using the Korean version of the Impact Event Scale-Revised (IES-R-K) and the Center for Epidemiologic Studies Depression Scale in 507 male firefighters. The PTSD symptom group was defined as those with a score of 25 or higher on the IES-R-K. Multiple logistic regression analysis was conducted to examine the covariates for the PTSD symptom group.
Out of 507 male firefighters, 139 (27.4%) had a score of 25 or more on the IES-R-K. The PTSD symptom group had lower plasma adiponectin levels than the controls. There was an inverse correlation between plasma adiponectin levels and PTSD severity. There was no correlation between adiponectin levels and depression. The adiponectin level was associated with the presence of PTSD symptom (odds ratio = 0.955, 95% CI = 0.920-0.991).
A cross-sectional design and using self-rated instruments.
To the best of our knowledge, the results showed that decreased adiponectin-mediated activity is associated with PTSD. Future studies are necessary to identify the causative role of adiponectin for PTSD as well as any possible covariates.
近期研究报道，脂联素介导的神经分子通路参与恐惧消退，这意味着脂联素可能是创伤后应激障碍（PTSD）的重要生物学标志物。然而，尚无研究调查脂联素与PTSD患者之间的关联。
我们使用韩语版修订版冲击事件量表（IES-R-K）和流行病学研究中心抑郁量表，对507名男性消防员的血浆脂联素水平、高敏C反应蛋白（hs-CRP）和心理病理因素进行了检测。PTSD症状组定义为IES-R-K得分25分及以上者。进行多因素逻辑回归分析以检验PTSD症状组的协变量。
在507名男性消防员中，139人（27.4%）的IES-R-K得分在25分及以上。PTSD症状组的血浆脂联素水平低于对照组。血浆脂联素水平与PTSD严重程度呈负相关。脂联素水平与抑郁之间无相关性。脂联素水平与PTSD症状的存在相关（比值比=0.955，95%可信区间=0.920-0.991）。
横断面设计且使用自评工具。
据我们所知，结果表明脂联素介导的活性降低与PTSD相关。未来有必要开展研究以确定脂联素在PTSD中的致病作用以及任何可能的协变量。
