Department of Otolaryngology-Head and Neck Surgery, Vanderbilt University, Nashville, Tennessee, USA.
Otolaryngol Head Neck Surg. 2011 Jul;145(1):154-60. doi: 10.1177/0194599810396624.
This study aims to identify factors that may help predict recurrence, the need for second-look operations, and other outcomes in the pediatric population.
Case series with chart review.
Tertiary medical center.
Five hundred and seventeen ears in 493 patients underwent primary acquired cholesteatoma resection over a 37-year period. Demographic (age, sex, and other medical conditions), cholesteatoma laterality, presence of perforation or otorrhea on otoscopic exam, preoperative and most recent audiologic data, and detailed intraoperative data were collected.
Overall, 47.2% of patients underwent second-look operations, with 48.0% having recurrent cholesteatoma visualized with attic recurrence being the most common location. In total, 22.7% of all patients in this study had recurrent disease. Factors at initial operation associated with a statistically significant increased risk of recurrence included cholesteatoma in the sinus tympani (odds ratio = 2.09; 95% confidence interval, 1.36-3.22) and incus destruction (1.65; 1.01-2.71).
The authors have successfully identified multiple factors at the time of initial operation that can have significant postoperative implications.
本研究旨在确定有助于预测小儿患者复发、需要再次手术以及其他结局的因素。
病例系列,结合图表回顾。
三级医疗中心。
517 耳在 493 例患者中进行了原发性获得性胆脂瘤切除术,研究时间跨度为 37 年。收集了人口统计学资料(年龄、性别和其他医疗条件)、胆脂瘤的侧别、耳镜检查时是否存在穿孔或耳漏、术前和最近的听力数据以及详细的术中数据。
总体而言,47.2%的患者进行了再次手术,其中 48.0%的患者出现了可见的复发性胆脂瘤,其中以 attic 复发最为常见。在这项研究中,总共有 22.7%的患者患有复发性疾病。与初次手术相关的与复发风险显著增加的因素包括鼓窦内的胆脂瘤(比值比=2.09;95%置信区间,1.36-3.22)和砧骨破坏(1.65;1.01-2.71)。
作者已经成功确定了初次手术时的多个因素,这些因素可能会对术后产生重大影响。