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代乳对母源抗体向仔猪传递支原体肺炎的影响。

Effect of cross-fostering on transfer of maternal immunity to Mycoplasma hyopneumoniae to piglets.

机构信息

Veterinary Population Medicine, College of Veterinary Medicine, University of Minnesota, St Paul, MN 55108, USA.

出版信息

Vet Rec. 2011 Jan 29;168(4):100. doi: 10.1136/vr.c6163. Epub 2011 Jan 26.

Abstract

The aim of this study was to assess the effect of cross-fostering on transfer of maternal Mycoplasma hyopneumoniae-specific humoral and cell-mediated immunity (CMI) from gilts to piglets. Cross-fostering, carried out within gilt pairs, was based on the gilts' M hyopneumoniae vaccination status in accordance with the following scheme: six pairs of vaccinated gilt × non-vaccinated gilt (V × N); five pairs of non-vaccinated gilt × vaccinated gilt (N × V); and five pairs of vaccinated gilt × vaccinated gilt (V × V). The piglets were cross-fostered at 0, six, 12 or 20 hours after birth. Two piglets per gilt per time point were cross-fostered (that is, eight piglets per gilt were moved) and the remaining piglets served as non-cross-fostered controls. In addition, four litters served as non-cross-fostered controls. A maximum of 10 piglets per gilt were sampled. The piglets' M hyopneumoniae-specific humoral immunity was assessed by ELISA and their CMI was assessed by delayed-type hypersensitivity testing. M hyopneumoniae-specific antibodies were detected in non-cross-fostered piglets from vaccinated dams and from piglets cross-fostered within the V × N gilt pair at six hours or more, and within the V × V gilt pair at all time points. Piglets cross-fostered within the N × V gilt pair had detectable M hyopneumoniae-specific antibodies only if they had been moved within six hours of birth. The transfer of M hyopneumoniae-specific CMI to piglets appeared to be source-dependent, and was detected only in piglets maintained on their vaccinated dams for at least 12 hours after birth.

摘要

本研究旨在评估交叉寄养对母猪母源支原体肺炎特异性体液和细胞介导免疫(CMI)向仔猪转移的影响。根据以下方案,在母猪之间进行交叉寄养,以母猪支原体肺炎疫苗接种状态为基础:6 对接种母猪×未接种母猪(V × N);5 对未接种母猪×接种母猪(N × V);5 对接种母猪×接种母猪(V × V)。仔猪在出生后 0、6、12 或 20 小时进行交叉寄养。每个时间点每个母猪寄养 2 头仔猪(即,每个母猪转移 8 头仔猪),其余仔猪作为未交叉寄养对照。此外,4 窝仔猪作为未交叉寄养对照。每个母猪最多采集 10 头仔猪。通过 ELISA 评估仔猪支原体肺炎特异性体液免疫,通过迟发型超敏反应试验评估 CMI。从接种疫苗的母猪和在 V × N 母猪间至少 6 小时或更晚进行交叉寄养的仔猪中检测到非交叉寄养仔猪的支原体肺炎特异性抗体,以及在所有时间点 V × V 母猪间进行交叉寄养的仔猪。在 N × V 母猪间进行交叉寄养的仔猪只有在出生后 6 小时内转移才能检测到支原体肺炎特异性抗体。向仔猪转移支原体肺炎特异性 CMI 似乎取决于来源,并且仅在出生后至少 12 小时维持在接种母猪上的仔猪中检测到。

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