HIV 药物研究中心的 HIV 蛋白酶和逆转录酶药物敏感性预测服务。

Services for prediction of drug susceptibility for HIV proteases and reverse transcriptases at the HIV drug research centre.

机构信息

Department of Pharmaceutical Biosciences, Uppsala University, Uppsala, Sweden.

出版信息

Bioinformatics. 2011 Jun 15;27(12):1719-20. doi: 10.1093/bioinformatics/btr192. Epub 2011 Apr 14.

DOI:10.1093/bioinformatics/btr192

PMID:21493651

Abstract

SUMMARY

The HIV Drug Research Centre (HIVDRC) has established Web services for prediction of drug susceptibility for HIV proteases and reverse transcriptases. The services are based on two proteochemometric models which accepts a protease or reverse transcriptase sequence in amino acid form, and outputs the predicted drug susceptibility values. The predictions are based on a comprehensive analysis where all the relevant inhibitors are included, resulting in models with excellent predictive capabilities.

AVAILABILITY AND IMPLEMENTATION

The services are implemented as interoperable Web services (REST and XMPP), with supporting web pages to allow for individual analyses. A set of plugins were also developed which make the services available from the Bioclipse workbench for life science. Services are available at http://www.hivdrc.org/services.

摘要

艾滋病病毒药物研究中心（HIVDRC）已经建立了用于预测 HIV 蛋白酶和逆转录酶药物敏感性的网络服务。这些服务基于两个基于药效的化学计量模型，它们接受以氨基酸形式表示的蛋白酶或逆转录酶序列，并输出预测的药物敏感性值。这些预测是基于对所有相关抑制剂进行综合分析的基础上进行的，从而得到具有出色预测能力的模型。