Department of Biology, Boston University, Boston, MA, USA.
Autophagy. 2011 Jul;7(7):793-4. doi: 10.4161/auto.7.7.15695. Epub 2011 Jul 1.
Interactions between the Bcl-2 family proteins and the mitochondrial fission and fusion machinery regulate cell death in mammals and worms. In Drosophila, the Bcl-2 family proteins have not been shown to be major regulators of cell death. However, emerging evidence suggests that mitochondrial remodeling may be important in Drosophila cell death. We recently demonstrated a series of events that occur during follicle removal in the Drosophila ovary that included mitochondrial remodeling and clustering, followed by uptake and degradation in the follicle cells. Importantly, the Bcl-2 family proteins, mitochondrial dynamics, and autophagic proteins regulate these events.
Bcl-2 家族蛋白与线粒体分裂和融合机制之间的相互作用调节哺乳动物和蠕虫的细胞死亡。在果蝇中，Bcl-2 家族蛋白尚未被证明是细胞死亡的主要调节剂。然而，新出现的证据表明线粒体重塑可能在果蝇细胞死亡中很重要。我们最近证明了在果蝇卵巢滤泡去除过程中发生的一系列事件，包括线粒体重塑和聚类，随后在滤泡细胞中被摄取和降解。重要的是，Bcl-2 家族蛋白、线粒体动力学和自噬蛋白调节这些事件。
