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抑郁患者接受丙咪嗪和电抽搐治疗后血小板 5-羟色胺摄取的活性

Active platelet 5-ht uptake in depressives treated with impramine and ect.

机构信息

P.K. DALAL, M.D., Associate Professor, Department Psychiatry, K.G.'s Medical College, Lucknow.

出版信息

Indian J Psychiatry. 1998 Jan;40(1):60-6.

PMID:21494445
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2964820/
Abstract

Several studies have reported decreased platelet 5-HT uptake in patients of major depression. The present study was undertaken with the aim to study the active platelet 5-HT uptake in depressed patients and effect of treatment with imipramine/ECT on platelet 5-HT uptake in these patients. 30 patients of major depression and equal number of age and sex-matched controls were included in the study. The depressives received imipramine (N=15) or ECT (N=15). Pretreatment active platelet 5-HT uptake was lower in depressives. Treatment with imipramine resulted in significant decrease in 5-HT uptake while with ECT there was significant increase. The serotonergic mechanisms are discussed.

摘要

几项研究报告指出，重度抑郁症患者的血小板 5-羟色胺摄取减少。本研究旨在研究抑郁症患者的活跃血小板 5-羟色胺摄取情况，以及用丙咪嗪/ECT 治疗对这些患者血小板 5-羟色胺摄取的影响。研究纳入了 30 名重度抑郁症患者和与之年龄、性别匹配的对照组。抑郁症患者接受丙咪嗪（N=15）或电抽搐治疗（N=15）。治疗前，抑郁症患者的血小板 5-羟色胺摄取活性较低。丙咪嗪治疗可显著降低 5-羟色胺摄取，而电抽搐治疗则显著增加。本文讨论了 5-羟色胺能机制。

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Ect and platelet 5ht uptake in major depression.重性抑郁障碍患者的内皮素和血小板 5-羟色胺摄取。
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