单次电休克治疗后的血小板5-羟色胺转运

Platelet serotonin transport after a single ECT.

作者信息

Rausch J L, Rich C L, Risch S C

机构信息

Department of Psychiatry, San Diego VAMC, School of Medicine, University of California, La Jolla 92093.

出版信息

Psychopharmacology (Berl). 1988;95(1):139-41. doi: 10.1007/BF00212783.

DOI:10.1007/BF00212783

PMID:3133694

Abstract

Platelet 5-HT uptake was examined in six depressed patients before and after a single electroconvulsive treatment and compared with six age- and sex-matched controls. The depressed patients had a significantly (P less than 0.05) lower Vmax of platelet 5-HT uptake prior to ECT (22.9 +/- 7.6 pm/2 x 10 platelets) than did control subjects (37.5 +/- 9.1 SEM). After a single ECT treatment, the Vmax significantly (P less than 0.05) increased to levels (34.6 +/- 10.1)no longer significantly different from control. The results are compared with recent data from depressed patients indicating that low baseline levels of platelet imipramine binding increase after ECT treatment.

摘要

对6名抑郁症患者在单次电休克治疗前后的血小板5-羟色胺摄取情况进行了检测，并与6名年龄和性别匹配的对照组进行比较。抑郁症患者在电休克治疗前血小板5-羟色胺摄取的最大速率（Vmax）显著（P<0.05）低于对照组（22.9±7.6 pm/2×10血小板）（对照组为37.5±9.1标准误）。单次电休克治疗后，Vmax显著（P<0.05）升高至与对照组无显著差异的水平（34.6±10.1）。这些结果与抑郁症患者的近期数据进行了比较，这些数据表明电休克治疗后血小板丙咪嗪结合的低基线水平会升高。