性行为与 HIV 传播和抗逆转录病毒治疗：HIV/AIDS 患者中行为风险因素的前瞻性队列研究。
Sexual HIV transmission and antiretroviral therapy: a prospective cohort study of behavioral risk factors among men and women living with HIV/AIDS.
机构信息
Department of Psychology, University of Connecticut, 406 Babbidge Road, Storrs, CT 06269, USA.
出版信息
Ann Behav Med. 2011 Aug;42(1):111-9. doi: 10.1007/s12160-011-9271-3.
Abstract
BACKGROUND
Using antiretroviral therapies for HIV prevention relies on patient adherence and avoidance of co-occurring sexually transmitted infections.
PURPOSE
The objective of this study is to simultaneously examine HIV treatment adherence and sexual risks for HIV transmission.
METHODS
This study is a prospective cohort of 201 men and 55 women diagnosed with HIV/AIDS infection.
RESULTS
A total of 32% men and 39% women engaged in unprotected intercourse with at least one HIV negative or unknown HIV status sex partner over 12 months. Nearly half (46%) of participants with HIV negative or unknown HIV status unprotected sex partners had detectable HIV viral load and were significantly more likely to have contracted a sexually transmitted infection since their HIV diagnosis. Individuals at higher risk for transmitting HIV were also less adherent to antiretroviral therapies.
CONCLUSIONS
Programs that aim to use antiretroviral therapies for HIV prevention require careful attention to adherence, sexually transmitted co-infections, and substance use.
摘要
背景
利用抗逆转录病毒疗法进行 HIV 预防依赖于患者的坚持和避免同时发生的性传播感染。
目的
本研究的目的是同时检查 HIV 治疗依从性和 HIV 传播的性风险。
方法
这是一项对 201 名男性和 55 名女性进行的前瞻性队列研究，他们被诊断患有 HIV/AIDS 感染。
结果
在 12 个月内，共有 32%的男性和 39%的女性与至少一名 HIV 阴性或未知 HIV 状态的性伴侣发生无保护性行为。近一半（46%）与 HIV 阴性或未知 HIV 状态的无保护性行为伴侣的参与者的 HIV 病毒载量可检测到，并且自 HIV 诊断以来，他们更有可能感染性传播感染。HIV 传播风险较高的个体也较少坚持抗逆转录病毒治疗。
结论
旨在利用抗逆转录病毒疗法进行 HIV 预防的计划需要仔细注意依从性、性传播合并感染和物质使用。
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