Department of Psychiatry, College of Physicians and Surgeons, Columbia University and the New York State Psychiatric Institute, New York, NY, USA.
Int J Eat Disord. 2012 Mar;45(2):290-3. doi: 10.1002/eat.20924. Epub 2011 Apr 14.
The purpose of this study was to assess eating behavior in patients with anorexia nervosa before and after weight normalization and healthy controls using a standardized, multiple-item lunch meal paradigm.
Eighteen patients were studied shortly after inpatient admission and again after gaining to a BMI ≥ 19.5 kg m(-2) . Fifteen healthy controls were studied twice, ∼2-3 months apart.
When underweight, patients with AN consumed fewer total calories (364 ± 208 kcal) and a lower percentage of calories from fat (18% ± 10%) compared to controls (775 ± 228 kcal, p = 0.001; 38% ± 7%, p = 0.001). After weight normalization, despite a modest increase in total calories (364 ± 208 kcal vs. 516 ± 273 kcal, p = 0.04) and in percent of calories from fat (18% ± 10% vs. 23% ± 9%, p = 0.04), patients continued to consume fewer total calories and a reduced percent of calories from fat compared to controls (758 ± 346 kcal, p = 0.03; 38% ± 18%, p = 0.004).
Patients with AN, even after acute treatment, consume fewer total calories and fewer calories from fat, compared to healthy controls. The reduced overall intake and persistent avoidance of fat may contribute to relapse, and therefore are potential therapeutic targets.
本研究旨在使用标准化的多项午餐模式评估神经性厌食症患者在体重正常化前后的进食行为，并与健康对照组进行比较。
18 名患者在住院后不久进行了研究，然后在 BMI 增加到≥19.5 kg/m²后再次进行研究。15 名健康对照组进行了两次研究，间隔约 2-3 个月。
当体重偏轻时，与对照组相比，神经性厌食症患者的总热量摄入较少（364±208 kcal），脂肪热量百分比较低（18%±10%）（p=0.001；38%±7%，p=0.001）。体重正常化后，尽管总热量摄入略有增加（364±208 kcal 比 516±273 kcal，p=0.04），脂肪热量百分比增加（18%±10%比 23%±9%，p=0.04），但与对照组相比，患者仍摄入较少的总热量和脂肪热量百分比（758±346 kcal，p=0.03；38%±18%，p=0.004）。
即使经过急性治疗，神经性厌食症患者的总热量和脂肪热量百分比仍低于健康对照组。总体摄入量减少和对脂肪的持续回避可能导致复发，因此是潜在的治疗靶点。
