Centre for Advanced Optoelectronic Functional Materials Research, Northeast Normal University, Changchun, PR China.
Nanotoxicology. 2012 May;6(3):241-8. doi: 10.3109/17435390.2011.570462. Epub 2011 Apr 17.
The effects of zinc oxide nanoparticles (ZnO NPs) on the root growth, root apical meristem mitosis and mitotic aberrations of garlic (Allium sativum L.) were investigated. ZnO NPs caused a concentration-dependent inhibition of root length. When treated with 50 mg/L ZnO NPs for 24 h, the root growth of garlic was completely blocked. The 50% inhibitory concentration (IC(50)) was estimated to be 15 mg/L. The mitosis index was also decreased in a concentration- and time-dependent manner. ZnO NPs also induced several kinds of mitotic aberrations, mainly consisted of chromosome stickiness, bridges, breakages and laggings. The total percentage of abnormal cells increased with the increase of ZnO NPs concentration and the prolongation of treatment time. The investigation provided new information for the possible genotoxic effects of ZnO NPs on plants.
研究了氧化锌纳米粒子（ZnO NPs）对大蒜（Allium sativum L.）根生长、根尖分生组织有丝分裂和有丝分裂异常的影响。ZnO NPs 对根长的抑制呈浓度依赖性。当用 50 mg/L ZnO NPs 处理 24 h 时，大蒜的根生长完全被阻断。估计 50%抑制浓度（IC(50)）为 15 mg/L。有丝分裂指数也呈浓度和时间依赖性下降。ZnO NPs 还诱导了几种类型的有丝分裂异常，主要包括染色体粘连、桥、断裂和滞后。异常细胞的总百分比随着 ZnO NPs 浓度的增加和处理时间的延长而增加。该研究为 ZnO NPs 对植物可能的遗传毒性效应提供了新信息。
