Neuroscience, NCI, Shanghai, 200001, China.
CNS Neurol Disord Drug Targets. 2011 Jun;10(4):433-9. doi: 10.2174/187152711795563985.
Neurogenesis occurs in the adult brain in a constitutive manner under physiological circumstances within two regions: the dentate gyrus of the hippocampus and the subventricular zone of the lateral ventricles. In contrast to these two so-called neurogenic areas, other regions of the brain were considered to be primarily non-neurogenic in nature, implying that no new neurons were formed there under normal conditions. Recently, low proliferative activity was reported in the hypothalamus and the cell layers surrounding the third ventricle. This review summarizes recent evidence for adult neurogenesis in the hypothalamus, and points out the potential contributions of these new neurons to neural processing. We also discussed some technical considerations in investigating neurogenesis in the adult hypothalamus. It is believed that the hypothalamus could serve as a new source and target for stem cell transplantation.
神经发生发生在成人脑内，在两个区域内以组成性方式在生理情况下发生：海马齿状回和侧脑室下区。与这两个所谓的神经发生区不同，大脑的其他区域被认为主要是非神经发生性质的，这意味着在正常情况下那里不会形成新的神经元。最近，在下丘脑和第三脑室周围的细胞层中报告了低增殖活性。这篇综述总结了最近关于成年下丘脑神经发生的证据，并指出了这些新神经元对神经处理的潜在贡献。我们还讨论了一些在研究成年下丘脑神经发生时的技术考虑因素。人们相信，下丘脑可以作为干细胞移植的新来源和靶标。
