Fernandes Carina, Rocha Nuno Barbosa F, Rocha Susana, Herrera-Solís Andrea, Salas-Pacheco José, García-García Fabio, Murillo-Rodríguez Eric, Yuan Ti-Fei, Machado Sergio, Arias-Carrión Oscar
Faculty of Medicine, University of Porto Porto, Portugal ; Laboratory of Neuropsychophysiology, Faculty of Psychology and Education Sciences, University of Porto Porto, Portugal.
School of Health Technologies, Polytechnic Institute of Porto Porto, Portugal.
Front Cell Neurosci. 2015 Apr 14;9:140. doi: 10.3389/fncel.2015.00140. eCollection 2015.
Adult mammalian brains continuously generate new neurons, a phenomenon called adult neurogenesis. Both environmental stimuli and endogenous factors are important regulators of adult neurogenesis. Sleep has an important role in normal brain physiology and its disturbance causes very stressful conditions, which disrupt normal brain physiology. Recently, an influence of sleep in adult neurogenesis has been established, mainly based on sleep deprivation studies. This review provides an overview on how rhythms and sleep cycles regulate hippocampal and subventricular zone neurogenesis, discussing some potential underlying mechanisms. In addition, our review highlights some interacting points between sleep and adult neurogenesis in brain function, such as learning, memory, and mood states, and provides some insights on the effects of antidepressants and hypnotic drugs on adult neurogenesis.
成年哺乳动物大脑持续产生新的神经元，这一现象称为成体神经发生。环境刺激和内源性因素都是成体神经发生的重要调节因子。睡眠在正常脑生理中具有重要作用，睡眠障碍会导致非常紧张的状况，扰乱正常脑生理。最近，主要基于睡眠剥夺研究，已证实睡眠对成体神经发生有影响。本综述概述了节律和睡眠周期如何调节海马体和脑室下区的神经发生，并讨论了一些潜在的潜在机制。此外，我们的综述强调了睡眠与成体神经发生在脑功能（如学习、记忆和情绪状态）方面的一些相互作用点，并提供了关于抗抑郁药和催眠药对成体神经发生影响的一些见解。
