Cao Jiancun, Wang Yan, Zhang Li, Ma Li
Graduate School, Tianjin Medical University, Tianjin, China.
Zhongguo Fei Ai Za Zhi. 2011 Apr;14(4):358-61. doi: 10.3779/j.issn.1009-3419.2011.04.10.
Quality of life (QoL) is an important end point in cancer patients, and depressive symptoms are significantly more frequent in lung cancer patients. The aim of this study is to observe the impact of chemotherapy on quality of life and emotion among lung cancer patients.
Fourty lung cancer patients were assessed with clinical outcomes, the EORTC QLQ-C30, SDS questionnaires before chemotherapy, one week after 2 cycles of chemotherapy, one week after 4 cycles of chemotherapy.
Before chemotherapy, the scores of functioning scales were high, the rate of depression was 65%. After 2 cycles of chemotherapy, effective rate was 42.5%, the scores of cognitive function increase, the scores of role, emotional, social function decrease, the scores of dyspnoea decrease, the scores of pain, appetite loss, insomnia, constipation, diarrhea increase, the scores of Global quality of life decrease; the rate of depression was 70%. After 4 cycles of chemotherapy, effective rate was 23%, the scores of physical, role, emotional, social function decrease, the scores of symptom scales increase, the scores of dyspnoea, nausea and vomiting, appetite loss, financial impact increase, the scores of global quality of life decrease, the rate of depression was 87.5%.
Some patients have symptoms relieved, but during the chemotherapy, the patients have significant depression, the quality of life decrease. We should evaluate the quality of life and emotions of lung cancer patients, and give positive psychological intervention to improve the quality of life.
生活质量（QoL）是癌症患者的一个重要终点，肺癌患者中抑郁症状明显更为常见。本研究的目的是观察化疗对肺癌患者生活质量和情绪的影响。
对40例肺癌患者在化疗前、化疗2周期后1周、化疗4周期后1周进行临床结局、欧洲癌症研究与治疗组织生活质量核心问卷（EORTC QLQ-C30）、抑郁自评量表（SDS）问卷调查。
化疗前，功能量表得分较高，抑郁发生率为65%。化疗2周期后，有效率为42.5%，认知功能得分增加，角色、情绪、社会功能得分下降，呼吸困难得分下降，疼痛、食欲减退、失眠、便秘、腹泻得分增加，总体生活质量得分下降；抑郁发生率为70%。化疗4周期后，有效率为23%，身体、角色、情绪、社会功能得分下降，症状量表得分增加，呼吸困难、恶心呕吐、食欲减退、经济影响得分增加，总体生活质量得分下降，抑郁发生率为87.5%。
部分患者症状缓解，但化疗期间患者抑郁明显，生活质量下降。应评估肺癌患者的生活质量和情绪，并给予积极的心理干预以提高生活质量。
