Liu Xu, Wang Yan, Li Shufang, Xin Shizhen, Cao Jiancun
Graduate School of Tianjin Medical University, Tianjin 300070, China;Department of Medical Oncology, Tianjin Medical University General Hospital, Tianjin 300052, China;Department of Respiration, Tianjin Xiqing Hospital, Tianjin 300380, China.
Zhongguo Fei Ai Za Zhi. 2013 Dec;16(12):656-60. doi: 10.3779/j.issn.1009-3419.2013.12.07.
With development of modern medicine, eliminating patients' pain and mental disorder and improving the quality of life has become an important problem in patients with cancer. The aim of this study is to observe the impact of chemotherapy on quality of life and influencing factor of quality of life among lung cancer patients.
Sixty-one lung cancer patients were assessed with clinical outcomes and the EORTC QLQ-C30 questionnaires before chemotherapy, one week after 2 cycles of chemotherapy, one week after 4 cycles of chemotherapy.
After 2 cycles of chemotherapy, effective rate was 40.0%. Social function decreased. Nause and vomiting, insomnia and appetite loss deteriorated (P<0.05). After 4 cycles of chemotherapy, effective rate was 23%. But after chemotherapy, physical, role, emotional, social function decreased; Appetite loss, nausea and vomiting, insomnia deteriorated, economics became difficult to some patients (P<0.05). In our study, we find female patients had more fatigue and appetite loss than male patients (P<0.05). Patients of low level of education had more fatigue and insomnia than patients of high level of education (P<0.05). Elder patients had more fatigue, appetite loss, nausea and vomiting than middle-aged patients (P<0.05). Grouped according to body mass index, the difference wasn't statistically significant (P>0.05). Grouped according to the plasma albumin level, the difference wasn't statistically significant (P>0.05). In hypoproteinemia group, symptoms and economic difficulties score was higher; High protein group, function and general health scores was higher.
After the chemotherapy, patients' the lesion of cancer became smaller and clinical symptoms relieved, but some patients, fatigue, appetite loss, nausea and vomiting symptom deteriorated, emotion became bad. Quality of life of lung cancer patients decrease. We should pay more attention to the adverse reactions of chemotherapy and cope with them, give positive psychological intervention and improve patients, nutrition to improve the quality of life.
随着现代医学的发展，消除患者的疼痛和精神障碍以及提高生活质量已成为癌症患者面临的一个重要问题。本研究旨在观察化疗对肺癌患者生活质量的影响以及生活质量的影响因素。
61例肺癌患者在化疗前、化疗2周期后1周、化疗4周期后1周，采用临床疗效和欧洲癌症研究与治疗组织生活质量核心问卷（EORTC QLQ-C30）进行评估。
化疗2周期后，有效率为40.0%。社会功能下降。恶心、呕吐、失眠和食欲减退加重（P<0.05）。化疗4周期后，有效率为23%。但化疗后，身体、角色、情感、社会功能下降；食欲减退、恶心、呕吐、失眠加重，部分患者经济困难（P<0.05）。在本研究中，我们发现女性患者比男性患者有更多的疲劳和食欲减退（P<0.05）。低学历患者比高学历患者有更多的疲劳和失眠（P<0.05）。老年患者比中年患者有更多的疲劳、食欲减退、恶心和呕吐（P<0.05）。按体重指数分组，差异无统计学意义（P>0.05）。按血浆白蛋白水平分组，差异无统计学意义（P>0.05）。低蛋白血症组症状和经济困难评分较高；高蛋白组功能和总体健康评分较高。
化疗后，患者的癌灶缩小，临床症状缓解，但部分患者疲劳、食欲减退、恶心、呕吐症状加重，情绪变差。肺癌患者的生活质量下降。我们应更加关注化疗的不良反应并加以应对，给予积极的心理干预，改善患者营养状况以提高生活质量。
