Medical Oncology, Izmir Research and Training Hospital, Bozyaka, 35360 Izmir, Turkey.
Support Care Cancer. 2010 Apr;18(4):417-21. doi: 10.1007/s00520-009-0679-2. Epub 2009 Jun 25.
The aim of the present study is to investigate variations in quality of life as a function of depression and anxiety scores of colorectal cancer patients with Beck depression and State-Trait Anxiety Inventory (STAI) scoring system.
One hundred ten patients with colorectal cancer undergoing chemotherapy who presented to Dokuz Eylul University Faculty of Medicine, Department of Oncology between January 2004 and April 2007 were included in this study. The series of forms including the questions regarding the demographic characteristics of the patient, Turkish version of the Beck Depression Inventory (BDI), the Turkish version of the STAI, and European Organization for Research and Treatment of Cancer Quality of Life Questionnaire C30 (EORTC-QLQ-C30; version 3) were completed during face-to-face interviews by trained interviewers to determine the psychological status and quality of life of the patients. The mean Beck depression scores were 11.2 +/- 9.0 (range 0-44) and the mean STAI scores were 41.9 +/- 8.8 (range 22-71). Of the patients (Beck depression scores >or=17 points), 23.6% were determined as depressive. The EORTC-QLQ-C30 function scales and global quality of life scores of the depressive patients (BDI >or= 17) were significantly lower than that of the nondepressive patients (BDI < 17). EORTC-QLQ-C30 symptom scale scores (excluding of the diarrhea) of the depressive patients were significantly higher than that of the nondepressive patients. The patients with low STAI scores (STAI < 45) had significantly higher EORTC-QLQ-C30 function scales and global quality of life scores than the patients with high STAI scores (STAI >or= 45). EORTC-QLQ-C30 symptom scale scores of the patients with high STAI scores were significantly higher than that of the patients with low STAI scores. In the present study, we detected that anxiety and depression were strongly associated with poor quality of life in Turkish colorectal cancer patients.
本研究旨在使用贝克抑郁自评量表（BDI）和状态-特质焦虑量表（STAI）评估结直肠癌患者的抑郁和焦虑评分与生活质量之间的关系。
本研究共纳入 2004 年 1 月至 2007 年 4 月期间在多乌泽尔大学医学院肿瘤学部接受化疗的 110 例结直肠癌患者。通过训练有素的访谈者，采用面对面访谈的方式，完成包括患者人口统计学特征、土耳其版贝克抑郁自评量表（BDI）、土耳其版状态-特质焦虑量表（STAI）和欧洲癌症研究与治疗组织生活质量问卷核心 30 项（EORTC-QLQ-C30；第 3 版）在内的一系列表格，以确定患者的心理状态和生活质量。患者的平均 BDI 评分为 11.2±9.0（范围 0-44），平均 STAI 评分为 41.9±8.8（范围 22-71）。在这些患者中（BDI 评分≥17 分），23.6%的患者被诊断为抑郁。抑郁患者的 EORTC-QLQ-C30 功能量表和总体生活质量评分明显低于非抑郁患者（BDI<17）。抑郁患者的 EORTC-QLQ-C30 症状量表评分（不包括腹泻）明显高于非抑郁患者。STAI 评分较低（STAI<45）的患者的 EORTC-QLQ-C30 功能量表和总体生活质量评分明显高于 STAI 评分较高（STAI≥45）的患者。STAI 评分较高的患者的 EORTC-QLQ-C30 症状量表评分明显高于 STAI 评分较低的患者。在本研究中，我们发现焦虑和抑郁与土耳其结直肠癌患者的生活质量差密切相关。
