National Resource Center for Late Effects, Department of Oncology, Oslo University Hospital, Radiumhospitalet, Montebello, 0310 Oslo, Norway.
Brain Behav Immun. 2011 Oct;25(7):1376-83. doi: 10.1016/j.bbi.2011.04.001. Epub 2011 Apr 7.
Chronic fatigue (CF) in breast cancer survivors (BCSs) has been associated with increased serum C-reactive protein-levels (CRP), pro-inflammatory cytokines and cytokine gene single nucleotide polymorphisms (SNPs). Still, there are few studies on these topics, and due to small study-cohorts the possibility to adjust for other conditions related to inflammatory processes, e.g. depression, has been limited. In 302 BCSs, examined approximately four years after treatment for breast cancer stage II/III, data on high sensitivity (hs)CRP, leukocytes and mRNA interleukin (IL)1β and IL6R expression, depression and chronic fatigue were available. Three years thereafter, 236 BCSs were re-examined. The associations between fatigue and SNPs in inflammation-related genes; IL1β (rs16944), IL6 (rs1800795), IL6receptor (rs4129267, rs4845617, rs2228145), CRP (rs2794521, rs3091244) were investigated, together with the relations between SNPs in IL6R,IL1β and CRP genes and mRNA blood expression levels of IL6R and IL1β and serum hsCRP-levels, respectively. All analyses were repeated after exclusion of depressed individuals and separating BCSs with persistent fatigue from never-fatigued individuals. Even after exclusion of depressed individuals neither the SNPs nor the mRNA IL1β and IL6R expression levels were associated with chronic or persistent fatigue. In the subset of persistent fatigued and never-fatigued individuals the CRP SNP (rs3091244) was associated with hsCRP level (p=0.02). IL1β and IL6R mRNA expression levels were not related to the IL1β and IL6R genotypes. In a large cohort of BCSs the investigated SNPs in inflammation-related genes were not associated with fatigue, though subset analyses indicated an association between the CRP SNP (rs3091244) and serum hsCRP.
慢性疲劳（CF）在乳腺癌幸存者（BCSs）中与血清 C 反应蛋白水平（CRP）升高、促炎细胞因子和细胞因子基因单核苷酸多态性（SNP）有关。然而，关于这些主题的研究很少，由于研究队列较小，调整与炎症过程相关的其他条件的可能性有限，例如抑郁。在 302 名接受 II/III 期乳腺癌治疗约四年后的 BCSs 中，可获得有关高敏（hs）CRP、白细胞和白细胞介素（IL）1β和 IL6R 表达、抑郁和慢性疲劳的数据。三年后，对 236 名 BCSs 进行了重新检查。研究了疲劳与炎症相关基因中的 SNP（IL1β（rs16944）、IL6（rs1800795）、IL6receptor（rs4129267、rs4845617、rs2228145）、CRP（rs2794521、rs3091244）之间的关联，以及 IL6R、IL1β 和 CRP 基因中的 SNP 与 IL6R 和 IL1β 的血液 mRNA 表达水平以及血清 hsCRP 水平之间的关系。在排除抑郁个体并将持续疲劳的 BCSs 与从未疲劳的个体分开后，重复了所有分析。即使排除了抑郁个体，SNP 也与慢性或持续性疲劳无关。在持续疲劳和从未疲劳的个体亚组中，CRP SNP（rs3091244）与 hsCRP 水平相关（p=0.02）。IL1β 和 IL6R mRNA 表达水平与 IL1β 和 IL6R 基因型无关。在 BCSs 的大型队列中，未发现炎症相关基因中的研究 SNP 与疲劳有关，尽管亚组分析表明 CRP SNP（rs3091244）与血清 hsCRP 之间存在关联。
