Department of Endodontics, Louisiana State University Health Sciences Center School of Dentistry, New Orleans, LA, USA.
J Endod. 2011 May;37(5):623-6. doi: 10.1016/j.joen.2011.02.010.
Squamous odontogenic tumor-like epithelial islands occurring in the walls of odontogenic cysts are histologically identical to the squamous odontogenic tumor (SOT). Microscopically, the squamous odontogenic tumor-like proliferations (SOTLPs) share certain histologic features with SOT, acanthomatous and desmoplastic ameloblastoma, and well-differentiated squamous cell carcinoma. Little is known about the rarely reported SOTLPs occurring in radicular cysts. The purpose of this study was to define the clinical and histopathologic spectrum of SOTLP in radicular cysts and to investigate its histogenesis, prevalence, and biologic behavior.
A retrospective clinicopathologic study was conducted at the Louisiana State University School of Dentistry, and a total of 42 radicular cysts with SOTLPs were accepted. Clinical findings and detailed histopathologic features were documented, and follow-up information was solicited for the 42 cases.
Forty-two cases of radicular cysts with SOTLPs were found among 1241 radicular cysts. Two thirds of the cases revealed the SOTLPs were arising from budlike extensions of the epithelial lining of the cyst. The SOT-like epithelial islands were in areas free of inflammatory cells in 73.8% of the cases. No evidence of recurrence or unexpected clinical behavior was reported in 11 cases with adequate follow-up.
The prevalence of SOTLPs in radicular cysts at Louisiana State University School of Dentistry is 3.4%. The SOTLPs appear to originate from the epithelial lining of the cyst and do not appear to be directly associated with inflammation. The biologic behavior of the radicular cyst with SOTLP is innocuous, with no apparent potential for neoplastic transformation or recurrence.
在牙源性囊肿的囊壁中出现的鳞状牙源性肿瘤样上皮岛与鳞状牙源性肿瘤（SOT）在组织学上是相同的。显微镜下，鳞状牙源性肿瘤样增生（SOTLP）与 SOT、棘层松解和促结缔组织增生型成釉细胞瘤以及分化良好的鳞状细胞癌具有某些组织学特征。关于在根型囊肿中罕见报道的 SOTLP 知之甚少。本研究的目的是确定 SOTLP 在根型囊肿中的临床和组织病理学谱，并研究其组织发生、流行率和生物学行为。
在路易斯安那州立大学牙科学院进行了回顾性临床病理研究，共接受了 42 例具有 SOTLP 的根型囊肿。记录了临床发现和详细的组织病理学特征，并为 42 例病例征求了随访信息。
在 1241 例根型囊肿中发现了 42 例具有 SOTLP 的根型囊肿。三分之二的病例显示 SOTLP 是从囊肿上皮衬里的芽状延伸中产生的。在 73.8%的病例中，SOT 样上皮岛位于无炎症细胞的区域。在 11 例具有足够随访的病例中，没有报告复发或意外临床行为的证据。
路易斯安那州立大学牙科学院根型囊肿中 SOTLP 的患病率为 3.4%。SOTLP 似乎起源于囊肿的上皮衬里，似乎与炎症没有直接关系。具有 SOTLP 的根型囊肿的生物学行为是无害的，没有明显的潜在肿瘤转化或复发的可能性。
