Ramachandran A, Snehalatha C, Premila L, Mohan V, Viswanathan M
Diabetes Research Centre, Royapuram, Madras, India.
Diabet Med. 1990 Dec;7(10):876-9. doi: 10.1111/j.1464-5491.1990.tb01322.x.
An analysis of 617 Type 1 (insulin-dependent) diabetic patients from 587 families was made. In 33 families (5.6%) there was more than one Type 1 diabetic patient. In 98 families (16.7%) positive family history of Type 2 (non-insulin-dependent) diabetes was present. There was a linear correlation between the age at diagnosis of the proband and that of the sibling (r = 0.73, p less than 0.001) in the Type 1 multiplex families. The risk of Type 1 diabetes in relatives was found to be 2.7% by Li Mantel estimate, which is lower than that reported among Europeans. The cumulative risk was higher (p less than 0.001) in the relatives of Type 1 diabetic patients with age at diagnosis less than or equal to 10 years.
对来自587个家庭的617名1型（胰岛素依赖型）糖尿病患者进行了分析。在33个家庭（5.6%）中有不止一名1型糖尿病患者。在98个家庭（16.7%）中存在2型（非胰岛素依赖型）糖尿病的阳性家族史。在1型多发家庭中，先证者与同胞的诊断年龄之间存在线性相关性（r = 0.73，p < 0.001）。通过Li Mantel估计，亲属患1型糖尿病的风险为2.7%，低于欧洲人报告的风险。诊断年龄小于或等于10岁的1型糖尿病患者的亲属中累积风险更高（p < 0.001）。
