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硫-33纳米颗粒：关于其作为中子俘获剂增强癌症硼中子俘获治疗潜力的蒙特卡罗研究

Sulfur-33 nanoparticles: a Monte Carlo study of their potential as neutron capturers for enhancing boron neutron capture therapy of cancer.

作者信息

Porras I

机构信息

Departamento de Física Atómica, Molecular y Nuclear, Facultad de Ciencias, Universidad de Granada, Granada, Spain.

出版信息

Appl Radiat Isot. 2011 Dec;69(12):1838-41. doi: 10.1016/j.apradiso.2011.04.002. Epub 2011 Apr 8.

DOI:10.1016/j.apradiso.2011.04.002
PMID:21497099
Abstract

In this paper, the potential effect of enhancing BNCT near the surface of the target volume by means of the addition of the sulfur isotope (33)S is studied. By means of Monte Carlo simulations, it is found a noticeable enhancement effect (local increase of the dose at the isotope site) when it is present at local concentrations that in principle can be reached by means of sulfur nanoparticles. A neutron beam with a high component of 13.5 keV would be required to produce this effect. Some open problems are discussed.

摘要

本文研究了通过添加硫同位素（33）S来增强硼中子俘获疗法（BNCT）在靶区表面附近的潜在效果。通过蒙特卡罗模拟发现，当以原则上可通过硫纳米颗粒实现的局部浓度存在时，会有显著的增强效果（同位素位点处剂量的局部增加）。产生这种效果需要具有高比例13.5 keV成分的中子束。文中讨论了一些未解决的问题。

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