Karpenko Marina N, Muruzheva Zamira M, Ilyechova Ekaterina Yu, Babich Polina S, Puchkova Ludmila V
I.P. Pavlov Department of Physiology, Research Institute of Experimental Medicine, 197376 St. Petersburg, Russia.
Institute of Biomedical Systems and Biotechnology, Peter the Great St. Petersburg Polytechnic University, 195251 St. Petersburg, Russia.
Antioxidants (Basel). 2023 Aug 22;12(9):1654. doi: 10.3390/antiox12091654.
In the last 15 years, among the many reasons given for the development of idiopathic forms of Parkinson's disease (PD), copper imbalance has been identified as a factor, and PD is often referred to as a copper-mediated disorder. More than 640 papers have been devoted to the relationship between PD and copper status in the blood, which include the following markers: total copper concentration, enzymatic ceruloplasmin (Cp) concentration, Cp protein level, and non-ceruloplasmin copper level. Most studies measure only one of these markers. Therefore, the existence of a correlation between copper status and the development of PD is still debated. Based on data from the published literature, meta-analysis, and our own research, it is clear that there is a connection between the development of PD symptoms and the number of copper atoms, which are weakly associated with the ceruloplasmin molecule. In this work, the link between the risk of developing PD and various inborn errors related to copper metabolism, leading to decreased levels of oxidase ceruloplasmin in the circulation and cerebrospinal fluid, is discussed.
在过去15年里，在为特发性帕金森病（PD）的发病提出的诸多原因中，铜失衡已被确定为一个因素，PD常被称为铜介导的疾病。超过640篇论文致力于研究PD与血液中铜状态之间的关系，其中包括以下标志物：总铜浓度、酶性铜蓝蛋白（Cp）浓度、Cp蛋白水平和非铜蓝蛋白铜水平。大多数研究仅测量这些标志物中的一种。因此，铜状态与PD发病之间是否存在相关性仍存在争议。基于已发表文献、荟萃分析和我们自己的研究数据，很明显PD症状的出现与铜原子数量之间存在联系，铜原子与铜蓝蛋白分子存在弱关联。在这项工作中，我们讨论了发生PD的风险与各种与铜代谢相关的先天性疾病之间的联系，这些疾病会导致循环和脑脊液中氧化酶铜蓝蛋白水平降低。
