Department of Human Movement Sciences, NUTRIM School for Nutrition, Toxicology and Metabolism, Maastricht University Medical Centre+, Maastricht, The Netherlands.
Diabetes Res Clin Pract. 2011 Jul;93(1):31-7. doi: 10.1016/j.diabres.2011.03.021. Epub 2011 Apr 16.
Although postprandial hyperglycemia is recognized as an important target in type 2 diabetes treatment, information on the prevalence of postprandial hyperglycemia throughout the day is limited. Therefore, we assessed the prevalence of hyperglycemia throughout the day in type 2 diabetes patients and healthy controls under standardized dietary, but otherwise free-living conditions.
60 male type 2 diabetes patients (HbA(1c) 7.5±0.1% [58±1 mmol/mol]) and 24 age- and BMI-matched normal glucose tolerant controls were recruited to participate in a comparative study of daily glycemic control. During a 3-day experimental period, blood glucose concentrations throughout the day were assessed by continuous glucose monitoring.
Type 2 diabetes patients experienced hyperglycemia (glucose concentrations >10 mmol/L) 38±4% of the day. Even diabetes patients with an HbA(1c) level below 7.0% (53 mmol/mol) experienced hyperglycemia for as much as 24±5% throughout the day. Hyperglycemia was negligible in the control group (3±1%).
Hyperglycemia is highly prevalent throughout the day in type 2 diabetes patients, even in those patients with a HbA(1c) level well below 7.0% (53 mmol/mol). Standard medical care with prescription of oral blood glucose lowering medication does not provide ample protection against postprandial hyperglycemia.
尽管餐后高血糖已被认为是 2 型糖尿病治疗的一个重要目标，但有关全天餐后高血糖发生率的信息有限。因此，我们评估了 2 型糖尿病患者和健康对照者在标准化饮食但其他方面自由生活条件下全天发生高血糖的情况。
60 名男性 2 型糖尿病患者（HbA1c7.5±0.1%[58±1mmol/mol]）和 24 名年龄和 BMI 匹配的正常糖耐量对照者被招募参与一项日常血糖控制的比较研究。在 3 天的实验期间，通过连续血糖监测评估全天的血糖浓度。
2 型糖尿病患者全天有 38±4%的时间出现高血糖（血糖浓度>10mmol/L）。即使 HbA1c 水平低于 7.0%（53mmol/mol）的糖尿病患者全天也有 24±5%的时间出现高血糖。对照组高血糖发生率为 3±1%。
即使在 HbA1c 水平远低于 7.0%（53mmol/mol）的 2 型糖尿病患者中，全天也普遍存在高血糖。常规医疗保健加上口服降血糖药物的处方并不能充分预防餐后高血糖。
