2型糖尿病患者步行锻炼对血糖控制的评估：一项随机交叉对照试验的系统评价和荟萃分析方案
Evaluation of walking exercise on glycemic control in patients with type 2 diabetes mellitus: A protocol for systematic review and meta-analysis of randomized cross-over controlled trials.
作者信息
Hu Hengchang, Lei Yuanhong, Yin Liping, Luo Xiaoqiong
机构信息
Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan Province.
Chongqing Traditional Chinese Medicine Hospital, Chongqing, China.
出版信息
Medicine (Baltimore). 2020 Nov 20;99(47):e22735. doi: 10.1097/MD.0000000000022735.
INTRODUCTION
Hyperglycemia is closely associated with the occurrence of diabetic complications, especially for patients with type 2 diabetes mellitus. Clinical trials indicated that walking exercise could improve glycemic control in patients with type 2 diabetes mellitus, but it is difficult to draw definitive and reliable conclusions due to the small sample size and possible exaggerated efficacy of various individual clinical trials. Therefore, we will conduct systematic review and meta-analysis to assess the current evidence for the efficacy of walking on glycemic control.
METHODS AND ANALYSIS
The databases of PubMed, EMBASE, Web of Science and Cochrane Library will be searched for this review. Cochrane risk-of-bias assessment tool will be applied to assess the risk of bias of included studies. A meta-analysis will be performed according to the Cochrane Handbook for Systematic Reviews of Interventions by using RevMan 5.3 and STATA/SE 14.0 software. Subgroup analysis will be conducted to investigate the sources of heterogeneity. Sensitivity analysis will be performed to assess the reliability and stability of the meta-analysis. Publication bias and small-study effects will be evaluated by a funnel plot and Eggers test if there are at least 10 studies. Additionally, the quality of evidence for this review will be assessed by Grades of Recommendations Assessment, Development and Evaluation (GRADE).
RESULTS
This systematic review and meta-analysis will be to assess the efficacy of walking exercise on glycemic control.
CONCLUSION
We will provide strong evidence to determine whether walking can improve glycemic control in patients with type 2 diabetes mellitus. This study is supposed to provide references for clinical trials and patients with type 2 diabetes mellitus.
ETHICS AND DISSEMINATION
This study does not require ethical approval. The results of this review will be published in a peer reviewed journal.
INPLASY REGISTRATION NUMBER
INPLASY202090046.
引言
高血糖与糖尿病并发症的发生密切相关，尤其是2型糖尿病患者。临床试验表明，步行锻炼可改善2型糖尿病患者的血糖控制，但由于样本量小以及各项单独临床试验可能存在的疗效夸大问题，难以得出明确可靠的结论。因此，我们将进行系统评价和荟萃分析，以评估步行对血糖控制疗效的现有证据。
方法与分析
将检索PubMed、EMBASE、Web of Science和Cochrane图书馆数据库进行本综述。将应用Cochrane偏倚风险评估工具评估纳入研究的偏倚风险。将根据Cochrane干预措施系统评价手册，使用RevMan 5.3和STATA/SE 14.0软件进行荟萃分析。将进行亚组分析以探究异质性来源。将进行敏感性分析以评估荟萃分析的可靠性和稳定性。如果有至少10项研究，将通过漏斗图和Egger检验评估发表偏倚和小研究效应。此外，将通过推荐分级评估、制定和评价（GRADE）评估本综述的证据质量。
结果
本系统评价和荟萃分析将评估步行锻炼对血糖控制的疗效。
结论
我们将提供有力证据，以确定步行是否能改善2型糖尿病患者的血糖控制。本研究应为临床试验和2型糖尿病患者提供参考。
伦理与传播
本研究无需伦理批准。本综述结果将发表在同行评审期刊上。
INPLASY注册号：INPLASY202090046。
Zotero 插件