Department of Endocrinology, Shandong Provincial Hospital, Cheeloo College of Medicine, Shandong University, 324 Jing 5 Road, Jinan, 250021, China.
Department of Endocrinology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, China.
BMC Endocr Disord. 2021 Mar 19;21(1):52. doi: 10.1186/s12902-021-00691-z.
There are many continuous blood glucose monitoring (CGM) data-based indicators, and most of these focus on a single characteristic of abnormal blood glucose. An ideal index that integrates and evaluates multiple characteristics of blood glucose has not yet been established.
In this study, we proposed the glycemic deviation index (GDI) as a novel integrating characteristic, which mainly incorporates the assessment of the glycemic numerical value and variability. To verify its effectiveness, GDI was applied to the simulated 24 h glycemic profiles and the CGM data of type 2 diabetes (T2D) patients (n = 30).
Evaluation of the GDI of the 24 h simulated glycemic profiles showed that the occurrence of hypoglycemia was numerically the same as hyperglycemia in increasing GDI. Meanwhile, glycemic variability was added as an independent factor. One-way ANOVA results showed that the application of GDI showed statistically significant differences in clinical glycemic parameters, average glycemic parameters, and glycemic variability parameters among the T2D groups with different glycemic levels.
In conclusion, GDI integrates the characteristics of the numerical value and the variability in blood glucose levels and may be beneficial for the glycemic management of diabetic patients undergoing CGM treatment.
目前有许多基于连续血糖监测（CGM）数据的指标，其中大多数指标都集中于血糖异常的单一特征。尚未建立一种能够综合评估血糖多个特征的理想指标。
本研究提出了血糖偏离指数（GDI）作为一种新的综合特征，主要纳入了血糖数值和变异性的评估。为了验证其有效性，我们将 GDI 应用于模拟的 24 小时血糖谱和 2 型糖尿病（T2D）患者的 CGM 数据（n=30）。
对 24 小时模拟血糖谱的 GDI 评估表明，低血糖的发生与 GDI 的增加在数值上是相同的，同时血糖变异性也被作为一个独立因素加入。单因素方差分析结果表明，在不同血糖水平的 T2D 组中，应用 GDI 在临床血糖参数、平均血糖参数和血糖变异性参数方面均表现出统计学差异。
总之，GDI 综合了血糖水平的数值和变异性特征，可能有利于接受 CGM 治疗的糖尿病患者的血糖管理。
