Laboratory of Developmental Biology & Genetics, Department of Molecular Biology, Faculty of Science, University of South Bohemia, Branišovská 31, 37005 České Budějovice, Czech Republic.
Reprod Biomed Online. 2011 Jun;22(6):512-5. doi: 10.1016/j.rbmo.2011.02.003. Epub 2011 Feb 13.
Genetic knockout studies in the mouse model first revealed the essential role of zygotically derived Cdx2 transcription factor during the later stages of blastocyst formation, characterized by a lack of functioning trophectoderm. However, the extent to which the potential provision of maternally derived Cdx2 affects preimplantation development has proved much less simple to address. Within the last year, two reports have been published arguing for and against a distinct functional role for maternal Cdx2. This commentary aims to discuss the approaches, results and interpretations of both studies in an attempt to resolve the apparent conflict and to constructively advance collective understanding.
在小鼠模型中的基因敲除研究首次揭示了合子来源的 Cdx2 转录因子在囊胚形成后期的重要作用，其特征是滋养外胚层功能缺失。然而，母源 Cdx2 的潜在提供在多大程度上影响着床前发育，事实证明要简单得多。在过去的一年中，有两份报告发表，分别支持和反对母源 Cdx2 具有独特的功能作用。本评论旨在讨论这两项研究的方法、结果和解释，试图解决明显的冲突，并建设性地推进集体理解。
