Laboratory of Cellular and Developmental Biology, NIDDK, National Institutes of Health, Bethesda, MD 20892, USA.
Development. 2010 Mar;137(6):859-70. doi: 10.1242/dev.039487.
The hiatus between oocyte and embryonic gene transcription dictates a role for stored maternal factors in early mammalian development. Encoded by maternal-effect genes, these factors accumulate during oogenesis and enable the activation of the embryonic genome, the subsequent cleavage stages of embryogenesis and the initial establishment of embryonic cell lineages. Recent studies in mice have yielded new findings on the role of maternally provided proteins and multi-component complexes in preimplantation development. Nevertheless, significant gaps remain in our mechanistic understanding of the networks that regulate early mammalian embryogenesis, which provide an impetus and opportunities for future investigations.
卵母细胞和胚胎基因转录之间的停顿决定了储存的母体因子在早期哺乳动物发育中的作用。这些因子由母体效应基因编码，在卵子发生过程中积累，并使胚胎基因组的激活、胚胎发生的后续分裂阶段以及胚胎细胞谱系的初始建立成为可能。最近在小鼠中的研究对母源性提供的蛋白质和多组分复合物在着床前发育中的作用有了新的发现。然而，在我们对调节早期哺乳动物胚胎发生的网络的机制理解方面仍存在很大差距，这为未来的研究提供了动力和机会。
