Nishijima Shota, Yanase Toru, Hata Yuki, Tamura Ryo, Tsuneki Ikunosuke, Tamura Masaki, Kurabayashi Takumi
Dept. of Obstetrics and Gynecology, Niigata City General Hospital, Japan.
Gan To Kagaku Ryoho. 2011 Apr;38(4):689-92.
The subject was a 75-year-old female who was receiving paclitaxel and carboplatin(TC)chemotherapy every other week after surgery for ovarian cancer. She greatly complained of taste disorders after four cycles(of every other week administration) of TC chemotherapy. To understand how the taste disorder was caused by chemotherapy objectively, taste examinations were conducted for the patient in our department. These examinations were conducted after receiving the informed consent from the patient. The authors conducted taste examinations for the patient using serum zinc measurement, tongue cell culture, electrogustometry, and filter paper disc tests(before and after starting chemotherapy), and found that her serum zinc level fell significantly after four cycles of chemotherapy. Orally disintegrating tablets of polaprezinc were then administered to the patient, after which the subjective symptom of taste disorder improved. Her serum zinc level increased, and the electrogustometric threshold rapidly fell(an improvement). The filter paper disc test showed some improvement, particularly in the glossopharyngeal nerve and the greater petrosal nerve field.
该患者为一名75岁女性，卵巢癌术后接受紫杉醇和卡铂（TC）化疗，每两周一次。在接受四个周期（每两周一次给药）的TC化疗后，她严重抱怨味觉障碍。为了客观了解化疗如何导致味觉障碍，我们科室对该患者进行了味觉检查。这些检查在获得患者知情同意后进行。作者对该患者进行了血清锌测量、舌细胞培养、电味觉测试和滤纸圆盘试验（化疗开始前后）等味觉检查，发现化疗四个周期后她的血清锌水平显著下降。然后给患者服用了泊拉普利锌口腔崩解片，之后味觉障碍的主观症状有所改善。她的血清锌水平升高，电味觉阈值迅速下降（有所改善）。滤纸圆盘试验显示有一定改善，尤其是在舌咽神经和岩大神经区域。
