Wojcik-Stanaszek Luiza, Gregor Anna, Zalewska Teresa
NeuroRepair Department, Mossakowski Medical Research Centre, Polish Academy of Sciences, Warsaw, Poland.
Acta Neurobiol Exp (Wars). 2011;71(1):103-12. doi: 10.55782/ane-2011-1827.
Deciphering the factors that regulate human neural stem cells will greatly aid in their use as models of development and as therapeutic agents. The complex interactions of cells with extracellular matrix (ECM) proteins probably contribute to proper central nervous system development mediating processes which regulate proliferation and differentiation of neural stem/rogenitor cells. Many of these interactions involve transmembrane integrin receptors. Integrins cluster in specific cell-matrix adhesions to provide dynamic links between extracellular and intracellular environments by activation of numerous signal transduction pathways which may influence cell behaviour profoundly by influence on both gene expression and post-transcriptional signalling cascade. In this review we introduced and discussed a number of extracellular and intracellular factors engaged in the transduction of signals induced by cell adhesion to its environment, including matrix components, extracellular proteolytic enzymes, integrins and non-receptor tyrosine kinases.
解析调控人类神经干细胞的因素将极大地有助于将其用作发育模型和治疗剂。细胞与细胞外基质（ECM）蛋白的复杂相互作用可能有助于中枢神经系统的正常发育，介导调节神经干/祖细胞增殖和分化的过程。这些相互作用中的许多涉及跨膜整合素受体。整合素聚集在特定的细胞-基质黏附中，通过激活众多信号转导途径在细胞外和细胞内环境之间提供动态联系，这些途径可能通过影响基因表达和转录后信号级联反应而深刻影响细胞行为。在这篇综述中，我们介绍并讨论了许多参与细胞与其环境黏附所诱导信号转导的细胞外和细胞内因素，包括基质成分、细胞外蛋白水解酶、整合素和非受体酪氨酸激酶。
