Department of Anesthesiolgy & Perioperative Medicine and School of Nursing, Queen's University, Kingston, Ontario.
Pain Res Manag. 2011 Mar-Apr;16(2):87-92. doi: 10.1155/2011/727094.
To examine the relationship between diet and lifestyle, and chronic widespread pain (CWP). If persons with CWP have dietary and lifestyle habits consistent with an increased risk of cancer or cardiovascular disease, it may partially explain evidence in the literature suggesting an association between CWP and these diseases.
The 1958 British Birth Cohort Study comprises individuals born in England, Scotland and Wales in the United Kingdom during one week in March 1958. At 45 years of age, pain was recorded using a self-completion questionnaire. CWP was classified using the American College of Rheumatology definition for fibromyalgia. Data were collected on diet and lifestyle at 33 and 42 years of age.
A total of 8572 participants provided pain data at 45 years of age, of whom 12% reported CWP. Women with CWP, compared with those without, reported an unhealthy diet (ie, fruit⁄vegetable consumption less than once per week [OR 2.0; 95% CI 1.3 to 3.1], and fatty food [OR 1.7; 95% CI 1.1 to 2.7] and chips (french fries) [OR 1.5; 95% CI 1.0 to 2.4] at least once per day) that may have predisposed them to other chronic diseases such as cancer and cardiovascular disease. Women with CWP were also more likely to be unemployed (adjusted OR 1.4; 95% CI 1.1 to 1.8), to have had high physical exertion at work (adjusted OR 1.6; 95% CI 1.2 to 2.2) and elevated body mass index (overweight - adjusted OR 1.5, 95% CI 1.2 to 1.9; obese - adjusted OR 1.8, 95% CI 1.3 to 2.5). Similar relationships between lifestyle (but not diet) and the risk of CWP were identified in men.
The findings for smoking, body mass index and (for women) diet offer support for the hypothesis that lifestyle factors may partially explain the association between CWP and cancer or cardiovascular disease. Prospective studies are necessary to confirm this relationship.
研究饮食和生活方式与慢性广泛性疼痛（CWP）之间的关系。如果患有 CWP 的人存在与癌症或心血管疾病风险增加相一致的饮食和生活习惯，那么这可能部分解释了文献中提示 CWP 与这些疾病之间存在关联的证据。
1958 年英国出生队列研究包括 1958 年 3 月一周内在英国英格兰、苏格兰和威尔士出生的个人。在 45 岁时，使用自我完成的问卷记录疼痛。使用美国风湿病学会纤维肌痛的定义来分类 CWP。在 33 岁和 42 岁时收集饮食和生活方式的数据。
共有 8572 名参与者在 45 岁时提供了疼痛数据，其中 12%报告患有 CWP。与没有 CWP 的女性相比，患有 CWP 的女性报告饮食不健康（即水果/蔬菜摄入量每周少于一次[OR 2.0；95%CI 1.3 至 3.1]，食用高脂肪食物[OR 1.7；95%CI 1.1 至 2.7]和薯片（炸薯条）[OR 1.5；95%CI 1.0 至 2.4]每天至少一次），这可能使她们容易患上其他慢性疾病，如癌症和心血管疾病。患有 CWP 的女性也更有可能失业（调整后的 OR 1.4；95%CI 1.1 至 1.8），工作时体力活动强度高（调整后的 OR 1.6；95%CI 1.2 至 2.2）和体重指数升高（超重-调整后的 OR 1.5，95%CI 1.2 至 1.9；肥胖-调整后的 OR 1.8，95%CI 1.3 至 2.5）。在男性中，也发现了生活方式（但不是饮食）与 CWP 风险之间的类似关系。
吸烟、体重指数和（女性）饮食方面的发现为生活方式因素可能部分解释 CWP 与癌症或心血管疾病之间关联的假设提供了支持。需要进行前瞻性研究来证实这种关系。
